In Situ Patterning of Microfluidic Networks in 3D Cell-Laden Hydrogels

被引：152

作者：

Brandenberg, Nathalie ^{[1
]}

Lutolf, Matthias P. ^{[1
,2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Lab Stem Cell Bioengn, CH-1015 Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Sch Basic Sci, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 34期

基金：

瑞士国家科学基金会;

关键词：

hydrogels; microfabrication; microfluidics; short-pulsed lasers; tissue engineering; FABRICATION; MATRIX; GROWTH; FATE;

D O I：

10.1002/adma.201601099

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Focalized short-pulsed lasers have sufficient power to generate micrometersized cavities in various hydrogels. An in situ technique based on laser ablation to fabricate intricate microfluidic networks in biocompatible gels without manual handling is presented. This method is fully compatible with 3D cell culture and opens up unprecedented opportunities for cell biology, developmental biology, and stem-cell-based tissue engineering.

引用

页码：7450 / 7456

页数：7

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