Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer

被引：3

作者：

Bae, Eun Young

Lee, Eun Jin

Kang, Hyo-Gyoung

Lee, Shin Yup ^{[2
]}

Jin, Gwang ^{[3
]}

Lee, Won Kee ^{[4
]}

Choi, Jin Eun

Jeon, Hyo-Sung

Lim, Jeong Ok ^{[5
]}

Lee, Eung Bae ^{[6
]}

Park, Jae Yong ^{[1
,2
]}

机构：

[1] Kyungpook Natl Univ, Med Ctr, Lung Canc Ctr, Sch Med,Dept Biochem & Cell Biol, Taegu 702210, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Taegu 702210, South Korea

[3] Yanbian Univ, Sch Basic Med, Dept Pharmacol, Yanji, Peoples R China

[4] Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Taegu 702210, South Korea

[5] Kyungpook Natl Univ, Sch Med, Biomed Res Inst, Taegu 702210, South Korea

[6] Kyungpook Natl Univ, Sch Med, Dept Thorac Surg, Taegu 702210, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2011年 / 26卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

Lung Neoplasms; Apoptosis; TP53; Mutation; Polymorphism; Genetic; P53; MUTATIONS; TUMORS; XPD;

D O I：

10.3346/jkms.2011.26.11.1527

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of TP53 mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and TP53 mutations in non-small cell lung cancer (NSCLC). Twenty-seven single nucleotide polymorphisms in 20 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with TP53 mutations in the entire coding exons (exons 2-11), including splicing sites of the gene, were analyzed. None of the 27 polymorphisms was significantly associated with the occurrence of TP53 mutations. This suggests that apoptosis-related genes may not play an important role in the occurrence of TP53 mutations in lung cancer.

引用

页码：1527 / 1530

页数：4

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