Effects of hydrophilicity/hydrophobicity of a drug on its release from PLGA films

被引：6
|
作者：
Liu, Hongze [1 ]
Qi, Min [1 ]
Guo, Bo [1 ]
Liu, Hui-hua [1 ]
机构：
[1] Dalian Univ Technol, Sch Mat Sci & Engn, Dalian 116024, Peoples R China
来源：
ADVANCED MATERIAL SCIENCE AND TECHNOLOGY, PTS 1 AND 2 | 2011年 / 675-677卷
关键词：
Hydrophilicity/hydrophobicity; Poly(dl-lactic-co-glycolic acid); Drug release; Degradation; IN-VITRO; DEGRADATION;
D O I：
10.4028/www.scientific.net/MSF.675-677.369
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Hydrophilic ciprofloxacin hydrochloride and hydrophobic sirolimus were used as model drugs, and poly(dl-lactic-co-glycolic acid) 50/50 (PLGA 50/50) was used as the drug carrier to investigate the effects of hydrophilicity/hydrophobicity of a drug on its release properties from PLGA films. The results showed that ciprofloxacin hydrochloride induced faster release curves than sirolimus, and it also promoted the weight loss of films, while sirolimus inhibited the weight loss of films. However, both drugs inhibited the degradation of biodegradable carrier.
引用
收藏
页码：369 / 372
页数：4
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