A Vero Cell-Derived Whole-Virus H5N1 Vaccine Effectively Induces Neuraminidase-Inhibiting Antibodies

被引：53

作者：

Fritz, Richard ^{[1
]}

Sabarth, Nicolas ^{[1
]}

Kiermayr, Stefan ^{[1
]}

Hohenadl, Christine ^{[1
]}

Howard, M. Keith ^{[1
]}

Ilk, Reinhard ^{[1
]}

Kistner, Otfried ^{[1
]}

Ehrlich, Hartmut J. ^{[2
]}

Barrett, P. Noel ^{[1
]}

Kreil, Thomas R. ^{[1
]}

机构：

[1] Baxter BioSci, Vaccine Res & Dev, Orth, Austria

[2] Baxter BioSci, Global Res & Dev, Vienna, Austria

来源：

JOURNAL OF INFECTIOUS DISEASES | 2012年 / 205卷 / 01期

关键词：

INFLUENZA-A VIRUS; WILD-TYPE VIRUS; IMMUNOLOGICAL RESPONSE; UNPRIMED POPULATIONS; VIRAL HEMAGGLUTININ; PRIOR EXPERIENCE; LINKED LECTIN; INFECTION; CULTURE; MICE;

D O I：

10.1093/infdis/jir711

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A Vero cell-derived whole-virus H5N1 influenza vaccine has been shown to induce neutralizing antibodies directed against the hemagglutinin (HA) protein of diverse H5N1 strains in animal studies and clinical trials. However, neuraminidase-inhibiting (NAi) antibodies can reduce viral spread and may be of particular importance in the event of an H5N1 pandemic, where immunity due to HA antibodies is likely absent in the general population. Here we demonstrate the effective induction of NAi antibody titers after H5N1 vaccination in humans. In contrast to the immune response directed toward HA, a single vaccine dose induced a strong NAi response that was not significantly boosted by a second dose, most probably due to priming by previous vaccination or infection with seasonal influenza viruses. After 2 immunizations, seroconversion rates based on antibody titers against HA and NA were similar, indicating the induction of equally strong immune responses against both proteins by this H5N1 vaccine.

引用

页码：28 / 34

页数：7

共 43 条

[1]

[Anonymous], Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO

[2]

Beutner K R, 1976, Dev Biol Stand, V33, P162

[3] EVALUATION OF A NEURAMINIDASE-SPECIFIC INFLUENZA-A VIRUS-VACCINE IN CHILDREN - ANTIBODY-RESPONSES AND EFFECTS ON 2 SUCCESSIVE OUTBREAKS OF NATURAL INFECTION [J].