Signal transduction by bone morphogenetic proteins

被引：434
作者：
Kawabata, M [1 ]
Imamura, T [1 ]
Miyazono, K [1 ]
机构：
[1] Japanese Fdn Canc Res, Inst Canc, Dept Biochem, Toshima Ku, Tokyo 1708455, Japan
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 1998年 / 9卷 / 01期
关键词：
bone morphogenetic protein; serine-threonine kinase receptor; signal transduction; Smad; Drosophila;
D O I：
10.1016/S1359-6101(97)00036-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which are members of the transforming growth factor-beta (TGF-beta) superfamily, Activities of BMPs are extracellularly regulated by BMP-binding proteins, Noggin and Chordin. BMPs bind to two different types of serine-threonine kinase receptors, type I and type II. Two BMP type I receptors and a BMP type LT receptor have been identified in mammals. Intracellular signals are transduced by Smad proteins. Smad1, Smad5 and probably MADH6, are activated by BMP receptors, form heteromeric complexes with Smad4, and translocate into the nucleus where they may activate transcription of various genes. Smad6 and Smad7 are inhibitory Smads, and may act as autocrine switch-off signals, In Drosophila melanogaster, Decapentaplegic (Dpp) is a homologue of mammalian BMPs, In this review, mechanism of action of Dpp will be discussed in comparison with that of BMPs, (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：49 / 61
页数：13
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