Crossroads between actinic keratosis and squamous cell carcinoma, and novel pharmacological issues

被引：0

作者：

Quatresooz, Pascale ^{[1
]}

Pierard-Franchimont, Claudine ^{[1
]}

Paquet, Philippe ^{[1
]}

Hubert, Pascale ^{[2
]}

Delvenne, Philippe ^{[2
]}

Pierard, Grald E. ^{[1
]}

机构：

[1] CHU Sart Tilman, Dept Dermatopathol, B-4000 Liege, Belgium

[2] CHU Sart Tilman, Dept Pathol, B-4000 Liege, Belgium

来源：

EUROPEAN JOURNAL OF DERMATOLOGY | 2008年 / 18卷 / 01期

关键词：

actinic keratosis; squamous cell carcinoma; epidermal growth factor receptor; imidazoquinoline; diclofenac; MAL photodynamic therapy;

D O I：

暂无

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Actinic keratoses (AKs) and their derived squamous cell carcinomas are distinctive lesions forming a continuum in a multi-step carcinogenesis process. They are typically found on chronically sun exposed skin. AKs merit to be recognized as such and to be distinguished from squamous cell carcinomas both conceptually and for therapeutic implications. The histological differences between these lesions are well defined and should not be blurred. A brief review is presented about the biological features responsible for AKs and the clinicopathologically distinctive aspects of these lesions. In addition, recent findings are presented about pharmacotherapy using anti-epidermal growth factor receptors, imidazoquinolines, diclofenac-hyaluronan, and methyl aminolevulinate photodynamic therapy.

引用

页码：6 / 10

页数：5

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