Poly(dimethylsiloxane) (PDMS) surface patterning by biocompatible photo-crosslinking block copolymers

被引：14

作者：

Kuroda, Keita ^{[1
]}

Miyoshi, Hiromi ^{[2
]}

Fujii, Shota ^{[3
]}

Hirai, Tomoyasu ^{[3
]}

Takahara, Atsushi ^{[3
,4
]}

Nakao, Aiko ^{[5
]}

Iwasaki, Yasuhiko ^{[6
]}

Morigaki, Kenichi ^{[7
]}

Ishihara, Kazuhiko ^{[8
]}

Yusa, Shin-ichi ^{[1
]}

机构：

[1] Univ Hyogo, Dept Mat Sci & Engn, Himeji, Hyogo 6712280, Japan

[2] RIKEN, Ctr Adv Photon, Wako, Saitama 3510198, Japan

[3] Kyushu Univ, Grad Sch Engn, Nishi Ku, Fukuoka 8190395, Japan

[4] Kyushu Univ, Inst Mat Chem & Engn, Nishi Ku, Fukuoka 8190395, Japan

[5] RIKEN, Nucl Spect Lab, Nishina Ctr Accelerator Based Sci, Wako, Saitama 3510198, Japan

[6] Kansai Univ, Fac Chem Mat & Bioengn, Suita, Osaka 5648660, Japan

[7] Kobe Univ, Res Ctr Environm Genom, Nada Ku, Kobe, Hyogo 6578501, Japan

[8] Univ Tokyo, Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

RSC ADVANCES | 2015年 / 5卷 / 58期

基金：

日本学术振兴会;

关键词：

POLY(2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE); 2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE; PHOSPHOLIPID POLYMERS; PROTEIN ADSORPTION; POLYDIMETHYLSILOXANE; BRUSHES; CELLS; POLYMERIZATION; BIOMATERIALS; PRESERVATION;

D O I：

10.1039/c5ra08843g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) possesses protein antifouling properties. Diblock copolymers (PMPC120-b-P(TSM/CEAx)(y)) composed of a PMPC block and random copolymer block with 3-(tris(trimethylsiloxy)silyl)propyl methacrylate (TSM) and 2-cinnamoylethyl acrylate (CEA) were prepared via reversible addition-fragmentation chain transfer (RAFT) radical polymerization. A thin film of PMPC120-P(TSM/CEAx)(y) formed on the surface of the poly(dimethylsiloxane) (PDMS) substrate due to physical adsorption of the TSM units to poly(dimethylsiloxane) (PDMS) and photo-crosslinking of the CEA units. A lattice pattern of PMPC120-P(TSM/CEAx)(y) on the PDMS surface was prepared using UV irradiation through a photomask. PMPC120-P(TSM/CEAx)(y)-coated PDMS demonstrated protein antifouling activity. Cell patterning could be achieved by culturing on the PMPC-patterned PDMS substrate.

引用

页码：46686 / 46693

页数：8

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