Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles

被引：463
作者：
Giljohann, David A. [1 ]
Seferos, Dwight S. [1 ]
Patel, Pinal C. [1 ]
Millstone, Jill E. [1 ]
Rosi, Nathaniel L. [1 ]
Mirkin, Chad A. [1 ]
机构：
[1] Northwestern Univ, Inst Nanotechnol, Dept Chem, Evanston, IL 60208 USA
来源：
NANO LETTERS | 2007年 / 7卷 / 12期
关键词：
D O I：
10.1021/nl072471q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated Ali the particle.
引用
收藏
页码：3818 / 3821
页数：4
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