A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach

被引:6
作者
Ricciardi, Valerio [1 ,2 ]
Blaha, Pavel [1 ,2 ]
Buompane, Raffaele [1 ]
Crescente, Giuseppina [3 ,4 ]
Cuttone, Giacomo [5 ]
Gialanella, Lucio [1 ,2 ]
Michalickova, Katarina [1 ,6 ]
Pacifico, Severina [1 ,3 ]
Porzio, Giuseppe [1 ,2 ]
Manti, Lorenzo [1 ,6 ]
机构
[1] Ist Nazl Fis Nucl INFN, Sez Napoli, I-80126 Naples, Italy
[2] Univ Campania Luigi Vanvitelli, Dipartimento Matemat & Fis, I-81100 Caserta, Italy
[3] Univ Campania Luigi Vanvitelli, Dipartimento Sci & Tecnol Ambientali Biol & Farma, I-81100 Caserta, Italy
[4] Univ Campania Luigi Vanvitelli, Dipartimento Med Sperimentale, I-81100 Caserta, Italy
[5] INFN, Lab Nazl Sud LNS, I-95123 Catania, Italy
[6] Univ Napoli Federico II, Dipartimento Fis E Pancini, I-80126 Naples, Italy
来源
APPLIED SCIENCES-BASEL | 2021年 / 11卷 / 24期
关键词
protontherapy; Proton-Boron Capture Therapy (PBCT); Proton-Boron Fusion-Enhanced Protontherapy (PBFEPT); BSH; low-energy protons; alpha particles; clonogenic survival; tandem accelerator; X-RAYS; CELLS; EXPOSURE; DAMAGE; BEAM;
D O I
10.3390/app112411986
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Featured Application The application of the work described herein is twofold: the possibility of routinely irradiating biological samples with high accuracy in energy and dose at a low-energy particle accelerator to gain insights into fundamental mechanisms of the biological action of charged particles; in a broader scenario, the possibility to potentiate the therapeutic capabilities of protontherapy through a method based on a nuclear physics reaction. Protontherapy (PT) is a fast-growing cancer therapy modality thanks to much-improved normal tissue sparing granted by the charged particles' inverted dose-depth profile. Protons, however, exhibit a low biological effectiveness at clinically relevant energies. To enhance PT efficacy and counteract cancer radioresistance, Proton-Boron Capture Therapy (PBCT) was recently proposed. PBCT exploits the highly DNA-damaging alpha-particles generated by the p + B-11 -> 3 alpha (pB) nuclear reaction, whose cross-section peaks for proton energies of 675 keV. Although a significant enhancement of proton biological effectiveness by PBCT has been demonstrated for high-energy proton beams, validation of the PBCT rationale using monochromatic proton beams having energy close to the reaction cross-section maximum is still lacking. To this end, we implemented a novel setup for radiobiology experiments at a 3-MV tandem accelerator; using a scattering chamber equipped with an Au foil scatterer for beam diffusion on the biological sample, uniformity in energy and fluence with uncertainties of 2% and 5%, respectively, was achieved. Human cancer cells were irradiated at this beamline for the first time with 685-keV protons. The measured enhancement in cancer cell killing due to the B-11 carrier BSH was the highest among those thus far observed, thereby corroborating the mechanistic bases of PBCT.
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页数:13
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