Alismanoid A, an unprecedented 1,2-seco bisabolene from Alisma orientale, and its protective activity against H2O2-induced damage in SH-SY5Y cells

被引：20

作者：

Yu, Zhen-Long ^{[1
]}

Peng, Yu-Lin ^{[1
]}

Wang, Chao ^{[1
]}

Cao, Fei ^{[2
]}

Huo, Xiao-Kui ^{[1
]}

Tian, Xiang-Ge ^{[3
]}

Feng, Lei ^{[1
]}

Ning, Jing ^{[1
]}

Zhang, Bao-Jing ^{[1
]}

Sun, Cheng-Peng ^{[1
]}

Ma, Xiao-Chi ^{[1
]}

机构：

[1] Dalian Med Univ, Coll Inst Integrat Med, Coll Pharm, 9,South Rd Lvshun, Dalian 116044, Peoples R China

[2] Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China

[3] Dalian Med Univ, Basic Med Coll, South Rd Lvshun, Dalian 116044, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2017年 / 41卷 / 21期

基金：

中国国家自然科学基金;

关键词：

ABSOLUTE-CONFIGURATION; CIRCULAR-DICHROISM; RHIZOMA; TRITERPENOIDS; APOPTOSIS; SESQUITERPENOIDS; CONSTITUENTS; AUTOPHAGY; EXTRACT; STRESS;

D O I：

10.1039/c7nj01806a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A pair of novel sesquiterpenoids, (8R)-alismanoid A (1a) and (8S)-alismanoid A (1b), possessing an unprecedented 1,2-seco bisabolene carbon skeleton, were isolated from rhizomes of Alisma orientale together with two new sesquiterpenoids: a 15-nor guaiane alismanoid B (2) and alismanoid C (3). Their structures were elucidated by 1D and 2D NMR, HRESIMS, electronic circular dichroism (ECD), and theoretical calculations, and a plausible biosynthetic pathway for compound 1 is discussed. Meanwhile, compounds 1-3 were investigated for their protective effects on H2O2-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y), and compounds 1b, 2, and 3 showed significantly protective activities at a certain concentration. Further, the action mechanism of compound 3 was proved to be through inhibition of H2O2-induced apoptosis in SH-SY5Y cells. Herein, these results suggest that sesquiter-penoids are potential candidate drugs for treating Parkinson's disease induced by reactive oxygen species.

引用

页码：12664 / 12670

页数：7

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