The immunological anatomy of the skin

被引：444

作者：

Kabashima, Kenji ^{[1
,2
,3
]}

Honda, Tetsuya ^{[1
]}

Ginhoux, Florent ^{[2
,3
,4
]}

Egawa, Gyohei ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Dermatol, Kyoto, Japan

[2] ASTAR, Singapore Immunol Network SIgN, Biopolis, Singapore, Singapore

[3] ASTAR, IMB, Biopolis, Singapore, Singapore

[4] Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Sch Med, Shanghai, Peoples R China

来源：

NATURE REVIEWS IMMUNOLOGY | 2019年 / 19卷 / 01期

基金：

日本学术振兴会;

关键词：

MEMORY T-CELLS; PERIVASCULAR ADIPOSE-TISSUE; ANTIGEN-PRESENTING CELLS; MATURE DENDRITIC CELLS; LANGERHANS CELLS; RESIDENT MEMORY; LYMPHOID-TISSUE; HAIR-FOLLICLES; HERPES-SIMPLEX; IMMUNE EVENTS;

D O I：

10.1038/s41577-018-0084-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The skin is the outermost organ of the body and is continuously exposed to external pathogens. Upon inflammation, various immune cells pass through, reside in or are recruited to the skin to orchestrate diverse cutaneous immune responses. To achieve this, immune cells interact with each other and even communicate with non-immune cells, including peripheral nerves and the microbiota. Immunologically important anatomical sites, such as skin appendages (for example, hair follicles and sweat glands) or postcapillary venules, act as special portal sites for immune cells and for establishing tertiary lymphoid structures, including inducible skin-associated lymphoid tissue. Here, we provide an overview of the key findings and concepts of cutaneous immunity in association with skin anatomy and discuss how cutaneous immune cells fine-tune physiological responses in the skin.

引用

页码：19 / 30

页数：12

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