Intracytoplasmic sperm injection increased fertilization and good-quality embryo formation in patients with non-male factor indications for in vitro fertilization: a prospective randomized study

被引:44
作者
Khamsi, F [1 ]
Yavas, Y [1 ]
Roberge, S [1 ]
Wong, JC [1 ]
Lacanna, IC [1 ]
Endman, M [1 ]
机构
[1] Toronto Feril Steril Inst, Toronto, ON M5R 3N8, Canada
关键词
IVF; ICSI; fertilization; oocyte; embryo;
D O I
10.1016/S0015-0282(00)01674-5
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To compare the fertilization rate and formation of good-quality embryos with conventional IVF and ICSI in patients with non-male factor infertility. Design: Prospective controlled study. Setting: Infertility clinic. Patient(s): Thirty-five patients with non-male factor infertility. Intervention(s): Retrieved sibling oocytes were randomly assigned to conventional IVF or ICSI. Of sibling oocytes assigned to ICSI, only metaphase II oocytes were injected with sperm. Main Outcome Measure(s): Fertilization rate and formation of good-quality embryos per retrieved oocyte. Result(s): Per retrieved oocyte, ICSI resulted in better fertilization rate compared with conventional IVF (71.3% [134 of 188] vs. 57.2% [107 of 187]). Per retrieved oocyte, ICSI also resulted in better formation of good-quality embryos at 48 hours after retrieval compared with conventional IVF (64.4% [121 of 188] vs. 47.1% [88 of 187]). Conclusion(s): In IVF patients with non-male factor infertility, subjecting some sibling oocytes to ICSI increased the fertilization rate and formation of good-quality embryos per retrieved oocyte. It also avoided the problem of total fertilization failure in almost all cases. (C)2001 by American Society for Reproductive Medicine.
引用
收藏
页码:342 / 347
页数:6
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