Meta-Analysis Comparing Complete or Culprit Only Revascularization in Patients With Multivessel Disease Presenting With Cardiogenic Shock

被引:8
作者
Bertaina, Maurizio [1 ]
Ferraro, Ilenia [1 ]
Omede, Pierlugi [1 ]
Conrotto, Federico [1 ]
Saint-Hilary, Gaelle [2 ]
Cavender, Matthew A. [3 ]
Claessen, Bimmer E. [4 ]
Henriques, Jose P. S. [4 ]
Frea, Simone [1 ]
Usmiani, Tullio [1 ]
Marra, Walter Grosso [1 ]
Pennone, Mauro [1 ]
Moretti, Claudio [1 ]
D'Amico, Maurizio [1 ]
D'Ascenzo, Fabrizio [1 ]
机构
[1] Molinette Mauriziano Hosp, Dept Cardiol, Citta Salute & Sci, Turin, Italy
[2] GL Lagrange Politecn Torino, Dept Math Sci, Turin, Italy
[3] Univ N Carolina, Dept Med, Div Cardiol, Chapel Hill, NC 27515 USA
[4] Acad Med Ctr, Dept Cardiol, Amsterdam, Netherlands
关键词
PERCUTANEOUS CORONARY INTERVENTION; ELEVATION MYOCARDIAL-INFARCTION; ST-SEGMENT ELEVATION; CHRONIC TOTAL OCCLUSIONS; ACUTE KIDNEY INJURY; RANDOMIZED-TRIAL; OUTCOMES; LESION; PCI; ANGIOPLASTY;
D O I
10.1016/j.amjcard.2018.08.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The optimal strategy for patients with an acute myocardial infarction (MI) and multivessel (MV) coronary artery disease complicated by cardiogenic shock (CS) remains unknown. We conducted a meta-analysis of all randomized controlled trials and observational studies that reported adjusted effect measures to evaluate the association of MV-PCI (percutaneous coronary intervention), compared with culprit only (C)-PCI, with cardiovascular events in patients admitted for CS and MV disease. We identified 12 studies (n =1 randomized controlled trials, n = 11 observational) that included 7,417 patients (n = 1,809 treated with MV-PCI and n = 5,608 with C-PCI). When compared with C-PCI, MV-PCI was not associated with an increased risk of short-term death (odds ratio [OR] 1.14, 95% confidence interval [CI] 0.87 to 1.48, p = 0.35 and adjusted OR [ORadj] 1.00, 95% CI 0.70 to 1.43, p = 1.00). In-hospital and/or short-term mortality tended to be higher with MV-PCI, when compared with C-PCI, for CS patients needing dialysis (-0.12, 95% CI from 0.049 to 0.198; p= 0.001), whereas MV-PCI was associated with lower in-hospital and/or short-term mortality in patients with an anterior MI (-0.022, 95% CI -0.03 to -0.01; p <0.001). MV-PCI strategy was associated with a more frequent need for dialysis or contrast-induced nephropathy after revascularization (OR 1.36, 95% CI -1.06 to -1.75, p = 0.02). In conclusion, MV-PCI seems not to increase risk of death during short- or long-term follow-up when compared with C-PCI in patients admitted for MV coronary artery disease and MI complicated by CS. Furthermore, it appears a more favorable strategy in patients with anterior MI, whereas the increased risk for AKI and its negative prognostic impact should be considered in decision-making process. Further studies are needed to confirm our hypothesis on in these subpopulations of CS patients. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:1661 / 1669
页数:9
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