Dismounting the MDR horse

被引:35
作者
Libby, Edward [1 ]
Hromas, Robert [1 ]
机构
[1] Univ New Mexico, Ctr Canc, Albuquerque, NM 87131 USA
关键词
ACUTE MYELOID-LEUKEMIA; RISK MYELODYSPLASTIC SYNDROME; RESISTANCE; TRIAL; CYCLOSPORINE; CYTARABINE; MODULATION; DIAGNOSIS; PSC-833; CANCER;
D O I
10.1182/blood-2010-09-304311
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:4037 / 4038
页数:4
相关论文
共 9 条
[1]   Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720 [J].
Baer, MR ;
George, SL ;
Dodge, RK ;
O'Loughlin, KL ;
Minderman, H ;
Caligiuri, MA ;
Anastasi, J ;
Powell, BL ;
Kolitz, JE ;
Schiffer, CA ;
Bloomfield, CD ;
Larson, RA .
BLOOD, 2002, 100 (04) :1224-1232
[2]   The impact of dose escalation and resistance modulation in older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome: the results of the LRF AML14 trial [J].
Burnett, Alan K. ;
Milligan, Donald ;
Goldstone, Anthony ;
Prentice, Archibald ;
McMullin, Mary-Frances ;
Dennis, Michael ;
Sellwood, Elizabeth ;
Pallis, Monica ;
Russell, Nigel ;
Hills, Robert K. ;
Wheatley, Keith .
BRITISH JOURNAL OF HAEMATOLOGY, 2009, 145 (03) :318-332
[3]  
CAMPOS L, 1992, BLOOD, V79, P473
[4]   Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999 [J].
Cripe, Larry D. ;
Uno, Hajime ;
Paietta, Elisabeth M. ;
Litzow, Mark R. ;
Ketterling, Rhett P. ;
Bennett, John M. ;
Rowe, Jacob M. ;
Lazarus, Hillard M. ;
Luger, Selina ;
Tallman, Martin S. .
BLOOD, 2010, 116 (20) :4077-4085
[5]   Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: A phase III trial (E2995) [J].
Greenberg, PL ;
Lee, SJ ;
Advani, R ;
Tallman, MS ;
Sikic, BI ;
Letendre, L ;
Dugan, K ;
Lum, B ;
Chin, DL ;
Dewald, G ;
Paietta, E ;
Bennett, JM ;
Rowe, JM .
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (06) :1078-1086
[6]   Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study [J].
List, AF ;
Kopecky, KJ ;
Willman, CL ;
Head, DR ;
Persons, DL ;
Slovak, ML ;
Dorr, R ;
Karanes, C ;
Hynes, HE ;
Doroshow, JH ;
Shurafa, M ;
Appelbaum, FR .
BLOOD, 2001, 98 (12) :3212-3220
[7]   The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis [J].
van der Holt, B ;
Löwenberg, B ;
Burnett, AK ;
Knauf, WU ;
Shepherd, J ;
Piccaluga, PP ;
Ossenkoppele, GJ ;
Verhoef, GEG ;
Ferrant, A ;
Crump, M ;
Selleslag, D ;
Theobald, M ;
Fey, MF ;
Vellenga, E ;
Dugan, M ;
Sonneveld, P .
BLOOD, 2005, 106 (08) :2646-2654
[8]  
Yin JAL, 2001, BRIT J HAEMATOL, V113, P713
[9]   Cancer Clinical Trials - A Chronic but Curable Crisis [J].
Young, Robert C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (04) :306-309