Cu-catalyzed direct C1-H difluoromethylation of pyrrolo[1,2-a] quinoxalines

被引：20

作者：

Li, Yang ^{[1
]}

Yang, Zhen ^{[1
]}

Liu, Yali ^{[1
]}

Liu, Yan ^{[1
]}

Gu, Yanlong ^{[1
]}

Liu, Ping ^{[1
]}

机构：

[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China

来源：

MOLECULAR CATALYSIS | 2021年 / 511卷

基金：

中国国家自然科学基金;

关键词：

Cu-catalyzed; C1-H difluoromethylation; Pyrrolo[1; 2-a]quinoxaline; Synthesis; VITRO ANTIMALARIAL ACTIVITY; IN-VITRO; BIOLOGICAL EVALUATION; RECENT PROGRESS; DERIVATIVES; INHIBITORS; DESIGN;

D O I：

10.1016/j.mcat.2021.111747

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An efficient Cu-catalyzed direct C1- H difluoromethylation of pyrrolo[1,2-a]quinoxalines with BrCF2CO2Et or BrCF2CONEt2 has been reported, providing to a series of difluoromethylated pyrrolo[1,2-a]quinoxalines with generally good yields. This approach features good compatibility with substituents, broad substrate scope, and gram-scale synthesis. The further transformations of the products are also examined.

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页数：8

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