Methylation of Amines and Ketones with Methanol Catalyzed by an Iridium Complex Bearing a 2-Hydroxypyridylmethylene Fragment

被引：86
作者：
Deng, Danfeng [1 ]
Hu, Bowen [1 ]
Yang, Min [1 ]
Chen, Dafa [1 ]
机构：
[1] Harbin Inst Technol, Sch Chem Engn & Technol, MIIT Key Lab Crit Mat Technol New Energy Convers, Harbin 150001, Heilongjiang, Peoples R China
来源：
ORGANOMETALLICS | 2018年 / 37卷 / 19期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
ASTERISK-IR COMPLEX; DEHYDROGENATIVE OXIDATION; BORROWING HYDROGEN; PRIMARY ALCOHOLS; N-METHYLATION; BIPYRIDONATE LIGAND; SECONDARY ALCOHOLS; ALPHA-ALKYLATION; EFFICIENT; TRANSFORMATION;
D O I：
10.1021/acs.organomet.8b00575
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Reaction of complex [Cp*Ir-(HOC5H3CH2C5H3OH)Cl][Cl] (1) with AgOTf generated the product [Cp*Ir(HOC5H3CH2C5H3OH)(H2O)][OTf](2) (2), which was further transformed to the complex [Cp*Ir-(OC5H3CH2C5H3O)(H2O)] (3) in the presence of t-BuONa via OH deprotonation. Complexes 1-3 exhibited high activity for the methylation of amines and ketones. These C-C and C-N coupling reactions proceeded in air with 1 mol % catalyst loading in the presence of K2CO3.
引用
收藏
页码：3353 / 3359
页数：7
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