Solubility study of ketoconazole in propylene glycol and ethanol mixtures at different temperatures: A laser monitoring method

被引：6
|
作者：
Jouyban-Gharamaleki, Vahid [1 ,2 ,3 ]
Jouyban, Abolghasem [1 ,2 ,4 ]
Zhao, Hongkun [5 ]
Martinez, Fleming [6 ]
Rahimpour, Elaheh [1 ,2 ,7 ]
机构：
[1] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran
[3] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan ICIPA Sci Based Co, Tabriz, Iran
[4] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[5] YangZhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China
[6] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim,Sede Bogota, Cra 30 45-03, Bogota, DC, Colombia
[7] Tabriz Univ Med Sci, Food & Drug Safety Res Ctr, Tabriz, Iran
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2021年 / 337卷
关键词：
Solubility; Ketoconazole; Cosolvency models; Dissolution thermodynamics; SOLID DISPERSIONS; WATER; MODEL; PHARMACOKINETICS; SOLVENTS;
D O I：
10.1016/j.molliq.2021.116060
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The solubility of ketoconazole in the mixtures of propylene glycol and ethanol is measured by a laser monitoring technique in the temperature range of 293.2-313.2 K. The generated solubility data are fitted to some linear and non-linear cosolvency models and the accuracy of each model is investigated by calculating the mean relative deviations (MRD%) for the back-calculated data. The apparent thermodynamic parameters of ketoconazole dissolution are also computed according to the van't Hoff and Gibbs equations. (C) 2021 Elsevier B.V. All rights reserved.
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页数：6
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