Solubility study of ketoconazole in propylene glycol and ethanol mixtures at different temperatures: A laser monitoring method

被引：6

作者：

Jouyban-Gharamaleki, Vahid ^{[1
,2
,3
]}

Jouyban, Abolghasem ^{[1
,2
,4
]}

Zhao, Hongkun ^{[5
]}

Martinez, Fleming ^{[6
]}

Rahimpour, Elaheh ^{[1
,2
,7
]}

机构：

[1] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[3] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan ICIPA Sci Based Co, Tabriz, Iran

[4] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[5] YangZhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

[6] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim,Sede Bogota, Cra 30 45-03, Bogota, DC, Colombia

[7] Tabriz Univ Med Sci, Food & Drug Safety Res Ctr, Tabriz, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2021年 / 337卷

关键词：

Solubility; Ketoconazole; Cosolvency models; Dissolution thermodynamics; SOLID DISPERSIONS; WATER; MODEL; PHARMACOKINETICS; SOLVENTS;

D O I：

10.1016/j.molliq.2021.116060

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubility of ketoconazole in the mixtures of propylene glycol and ethanol is measured by a laser monitoring technique in the temperature range of 293.2-313.2 K. The generated solubility data are fitted to some linear and non-linear cosolvency models and the accuracy of each model is investigated by calculating the mean relative deviations (MRD%) for the back-calculated data. The apparent thermodynamic parameters of ketoconazole dissolution are also computed according to the van't Hoff and Gibbs equations. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：6

共 37 条

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