Lysosomal size matters

被引：127

作者：

de Araujo, Mariana E. G. ^{[1
]}

Liebscher, Gudrun ^{[1
]}

Hess, Michael W. ^{[2
]}

Huber, Lukas A. ^{[1
,3
]}

机构：

[1] Med Univ Innsbruck, Bioctr, Inst Cell Biol, Innsbruck, Austria

[2] Med Univ Innsbruck, Inst Histol & Embryol, Innsbruck, Austria

[3] ADSI, Innsbruck, Austria

来源：

TRAFFIC | 2020年 / 21卷 / 01期

基金：

奥地利科学基金会;

关键词：

AMPK; autolysosome; autophagy; BORC; endolysosome; fission; fusion; LAMTOR; late endosome; lysosomal acidification; lysosomal reformation; lysosomal storage disorders; lysosome; PtdIns(4; 5)P-2; PIKfyve; PtdIns(3)P; PtdIns(3; V-ATPase; PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE; V-ATPASE; MOUSE MODEL; ELECTRON-MICROSCOPY; RAG GTPASES; GLUCOCEREBROSIDASE MUTATIONS; SUBCELLULAR-LOCALIZATION; FRONTOTEMPORAL DEMENTIA; PIKFYVE ACTIVITY; VACUOLAR ATPASE;

D O I：

10.1111/tra.12714

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra- and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes have a strong impact on lysosomal activity ultimately influencing cellular homeostasis. In this review, we summarize the current knowledge on lysosomal size regulation, on its physiological role(s) and association to several disease conditions.

引用

页码：60 / 75

页数：16

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