Direct asymmetric α-fluorination of aldehydes

被引：291
作者：
Steiner, DD
Mase, N
Barbas, CF
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 24期
关键词：
D O I：
10.1002/anie.200500571
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Linear and branched aldehydes are asymmetrically α-fluorinated with L-proline and pyrrolidine-based organocatalysts (see scheme; NFSi: N-fluorobenzenesulfonamide). In the first case, yields and enantioselectivities were high; in the second, the yields remained high and the enantioselectivities were moderate. Significantly, linear aldehydes were only monofluorinated. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
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页码：3706 / 3710
页数：5
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