The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats

被引：34

作者：

Lim, Siew-Na ^{[1
,2
,3
]}

Huang, Wenlong ^{[1
]}

Hall, Jodie C. E. ^{[1
]}

Ward, Rachael E. ^{[1
]}

Priestley, John V. ^{[1
]}

Michael-Titus, Adina T. ^{[1
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Ctr Neurosci & Trauma, Blizard Inst Cell & Mol Sci, London, England

[2] Chang Gung Mem Hosp, Dept Neurol, Taipei 10591, Taiwan

[3] Chang Gung Univ, Coll Med, Taipei, Taiwan

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2010年 / 83卷 / 4-6期

关键词：

Eicosapentaenoic acid; Omega-3 fatty acids; Spinal cord injury; Neuroprotection; NF-KAPPA-B; POLYUNSATURATED FATTY-ACIDS; ACTIVATION; EXPRESSION; RECOVERY; DECREASES;

D O I：

10.1016/j.plefa.2010.08.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the present study was to investigate the effects of treatment with eicosapentaenoic acid (EPA) after spinal cord compression injury in adult rats. Saline or EPA (250 nmol/kg) was administered intravenously 30 min after compression injury. Locomotor recovery was assessed daily using the BBB open-field locomotor score. One week after injury, animals were sacrificed and the spinal cord tissue containing the compression epicenter, and the adjacent rostral and caudal segments, was immunostained using specific markers for neurons, oligodendrocytes, axonal injury, and macrophages/microglia. Administration of EPA resulted in decreased axonal injury and increased neuronal and oligodendrocyte survival, in the lesion epicenter and adjacent tissue. The behavioural assessment mirrored the neuroprotective effects and showed a significantly improved functional recovery in animals treated with EPA compared to the saline-treated controls over the 7-day period. These observations suggest that EPA has neuroprotective properties when administered after spinal cord trauma. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：193 / 201

页数：9

共 32 条

[1] Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation [J].

Arita, Makoto ;

Ohira, Taisuke ;

Sun, Yee-Ping ;

Elangovan, Siva ;

Chiang, Nan ;

Serhan, Charles N. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3912-3917

[2] FUNCTION AMD ACTIVATION OF NF-KAPPA-B IN THE IMMUNE-SYSTEM [J].

BAEUERLE, PA ;

HENKEL, T .

ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 :141-179

[3] Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection [J].

Basso, DM ;

Beattie, MS ;

Bresnahan, JC .

EXPERIMENTAL NEUROLOGY, 1996, 139 (02) :244-256

[4]

Bethea JR, 1998, J NEUROSCI, V18, P3251

[5] CELLULAR MORPHOLOGY OF CHRONIC SPINAL-CORD INJURY IN THE CAT - ANALYSIS OF MYELINATED AXONS BY LINE-SAMPLING [J].

BLIGHT, AR .

NEUROSCIENCE, 1983, 10 (02) :521-&

[6] Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale [J].

Calder, Philip C. .

BIOCHIMIE, 2009, 91 (06) :791-795

[7] Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain [J].

Dyall, S. C. ;

Michael, G. J. ;

Whelpton, R. ;

Scott, A. G. ;

Michael-Titus, A. T. .

NEUROBIOLOGY OF AGING, 2007, 28 (03) :424-439

[8]

EIDELBERG E, 1981, EXP BRAIN RES, V42, P81

[9] THE RELATIONSHIPS AMONG THE SEVERITY OF SPINAL-CORD INJURY, RESIDUAL NEUROLOGICAL FUNCTION, AXON COUNTS, AND COUNTS OF RETROGRADELY LABELED NEURONS AFTER EXPERIMENTAL SPINAL-CORD INJURY [J].

FEHLINGS, MG ;

TATOR, CH .

EXPERIMENTAL NEUROLOGY, 1995, 132 (02) :220-228

[10] Effect of cyclopentanone prostaglandin 15-deoxy-Δ12,14PGJ2 on early functional recovery from experimental spinal cord injury [J].

Genovese, Tiziana ;

Esposito, Emanuela ;

Mazzon, Emanuela ;

Di Paola, Rosanna ;

Muia, Carmelo ;

Meli, Rosaria ;

Bramanti, Placido ;

Cuzzocrea, Salvatore .

SHOCK, 2008, 30 (02) :142-152

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