Towards optimizing peptide-based inhibitors of protein-protein interactions: predictive saturation variation scanning (PreSaVS)

被引：3

作者：

Hetherington, Kristina ^{[1
,2
]}

Dutt, Som ^{[1
,2
]}

Ibarra, Amaurys A. ^{[3
]}

Cawood, Emma E. ^{[1
,2
]}

Hobor, Fruzsina ^{[1
,4
]}

Woolfson, Derek N. ^{[3
,5
,6
]}

Edwards, Thomas A. ^{[1
,4
]}

Nelson, Adam ^{[1
,2
]}

Sessions, Richard B. ^{[3
,6
]}

Wilson, Andrew J. ^{[1
,2
]}

机构：

[1] Univ Leeds, Astbury Ctr Struct Mol Biol, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Sch Chem, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England

[3] Univ Bristol, Sch Biochem, Med Sci Bldg, Bristol BS8 1TD, Avon, England

[4] Univ Leeds, Sch Mol & Cellular Biol, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England

[5] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[6] Univ Bristol, BrisSynBio, Life Sci Bldg,Tyndall Ave, Bristol BS8 1TQ, Avon, England

来源：

RSC CHEMICAL BIOLOGY | 2021年 / 2卷 / 05期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

SMALL-MOLECULE INHIBITORS; RECOGNITION; DISCOVERY; INSIGHTS; MOTIFS;

D O I：

10.1039/d1cb00137j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.

引用

页码：1474 / 1478

页数：5

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