Studies on the biosynthesis of epothilones:: The PKS and epothilone C/D monooxygenase

被引：35

作者：

Gerth, K

Steinmetz, H

Höfle, G

Reichenbach, H

机构：

[1] Gesell Biotechnol Forsch GmbH, GBF, Abt Naturstoffbiol, D-38124 Braunschweig, Germany

[2] Gesell Biotechnol Forsch GmbH, GBF, Abt Naturstoffchem, D-38124 Braunschweig, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 02期

关键词：

D O I：

10.7164/antibiotics.54.144

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nonproducer mutants support the assumption that epothilones A and B are synthesized by the same polyketide synthase (PKS). The endproducts of the PKS, epothilones C and D, compete for the active site of a constitutively synthesized monooxygenase which is regulated by product inhibition. The postulated C-13 hydroxy-epothilones as direct precursors of epothilones C and D were not detected.

引用

页码：144 / 148

页数：5

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