Extraction of bioactive compounds from Curcuma longa L. using deep eutectic solvents: In vitro and in vivo biological activities

被引：39

作者：

Oliveira, Grazielle ^{[1
]}

Marques, Caroline ^{[1
]}

de Oliveira, Anielle ^{[2
]}

dos Santos, Amanda de Almeida ^{[4
]}

do Amaral, Wanderlei ^{[1
]}

Ineu, Rafael Porto ^{[2
]}

Leimann, Fernanda Vitoria ^{[2
,3
]}

Peron, Ana Paula ^{[4
]}

Igarashi-Mafra, Luciana ^{[1
]}

Mafra, Marcos R. ^{[1
]}

机构：

[1] Univ Fed Parana, Grad Program Food Engn, Dept Chem Engn, Av Francisco Heraclito Santo S-N 100, BR-81531980 Curitiba, Parana, Brazil

[2] Univ Tecnol Fed Parana, Postgrad Program Food Technol PPGTA, Campus Campo Mourao UTFPRCM, Via Rosalina Maria Santos 1233, BR-87301899 Campo Mourao, Parana, Brazil

[3] Inst Politecn Braganca, Ctr Investi Montanha CIMO, Campus Santa Apolonia, P-5300253 Braganca, Portugal

[4] Fed Univ Technol Parana UTFPR, Biodivers & Nat Conservat Dept, Campus Campo Mourao,Via Rosalina Maria Santos,123, BR-87301899 Campo Mourao, Parana, Brazil

来源：

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES | 2021年 / 70卷

关键词：

Antioxidant; Antibacterial; Iron-chelating; Cholinesterase; Cellular level toxicity; ULTRASOUND; ACID; ACETYLCHOLINESTERASE; LEAVES;

D O I：

10.1016/j.ifset.2021.102697

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

In this work, deep eutectic solvents (DES-based menthol and cholinium chloride) and the ethanol, temperature, and times were selected to extract bioactive compounds from the rhizome, leaves, and flowers Curcuma longa L., using ultrasound-assisted extraction. Analyzes antioxidant, flavonoids, antimicrobial, chelation Fe2+, inhibition of the cholinesterase's enzymes, cytotoxicity, and genotoxicity in Allium cepa cells were performed. The extracts showed results of iron chelation and antibacterial. Curcuma flowers and leaves' extracts inhibited food spoilage bacteria with values above 45%, with substantial iron-chelating activity above 50%. Extracts obtained by DES based on menthol and lactic acid exhibited a high percentage of inhibition of acetyl and butyryl cholinesterase. In contrast, flower extracts obtained by menthol and acetic acid showed low inhibition of cholinesterase enzyme activity. No extract showed cytotoxicity and genotoxicity. Biological activities showed a high potential for the application of these extracts in the food and pharmaceutical industries.

引用

页数：9

共 51 条

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