Abietane Diterpenoids and a Lignan from Pinus yunnanensis

被引：9

作者：

Feng, Tao ^{[1
,2
]}

Cai, Xiang-Hai ^{[1
]}

Tan, Qin-Gang ^{[1
]}

Luo, Xiao-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2010年 / 65卷 / 06期

关键词：

Pinus yunnanensis; Pinaceae; Diterpenoids; Lignan; Anti-inflammatory Activity; Cytotoxicity; METHIDE TUMOR INHIBITORS; TAXODIUM DISTICHUM; PROLIFERATION; CONSTITUENTS; TAXODONE; RESIN;

D O I：

10.1515/znb-2010-0614

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two new abietane diterpene acids, pinyunins A (1) and B (2), a new lignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(2,3-dihydroxyphenyl)propane-1,3-diol (3), and eight known diterpenoids (4-11) were isolated from the bark of Pinus yunnanensis Franch. Their structures were elucidated by spectroscopic methods. Compounds 1-3 exhibited high inhibitions on Cox-2 (> 80%) and low inhibitions on Cox-1 (< 50 %), showing the trend of selective inhibition of Cox-2, while the positive controls NS-398 (Cox-2) and SC-560 (Cox-1) gave inhibitions of 97.09% and 61.30%, respectively. Compounds 1-11 were evaluated for their cytotoxicity against five human cancer cell lines with Cisplatin as a positive control.

引用

页码：765 / 769

页数：5

共 16 条

[1]

Chen Ya, 2006, Acta Botanica Yunnanica, V28, P323

[2] FURTHER ACIDIC CONSTITUENTS AND NEUTRAL COMPONENTS OF PINUS-MASSONIANA RESIN [J].