Salivary glands: novel target sites for gene therapeutics

被引：49
作者：
Baum, BJ [1 ]
Voutetakis, A [1 ]
Wang, JH [1 ]
机构：
[1] Natl Inst Dental & Craniofacial Res, Gene Therapy & Therapeut Branch, NIH, DHHS, Bethesda, MD 20892 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 12期
关键词：
D O I：
10.1016/j.molmed.2004.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Directing the local or systemic expression of therapeutic proteins is a potentially important clinical application of gene transfer technology. Gene-based therapeutics theoretically offer many advantages over protein therapeutics. Numerous tissues have been evaluated for this purpose in animal models, most commonly the liver and skeletal muscle. Based on pre-clinical studies, we suggest that salivary glands are a valuable, yet underappreciated, target tissue for both systemic and upper gastrointestinal tract gene therapeutic applications.
引用
收藏
页码：585 / 590
页数：6
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