Somatic cell reprogramming as a tool for neurodegenerative diseases

被引：7

作者：

Ebrahimi, Ayyub ^{[1
]}

Keske, Ezgi ^{[1
]}

Mehdipor, Ahmad ^{[2
]}

Ebrahimi-Kalan, Abbas ^{[3
]}

Ghorbani, Meysam ^{[3
,4
]}

机构：

[1] Halic Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Istanbul, Turkey

[2] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Tissue Engn, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Neurosci & Cognit, Tabriz, Iran

[4] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 112卷

关键词：

Induced pluripotent stem cells; Neurodegenerative diseases; Somatic cell reprogramming; Transdifferentiation; PLURIPOTENT STEM-CELLS; AMYOTROPHIC-LATERAL-SCLEROSIS; ALZHEIMERS-DISEASE; MOUSE FIBROBLASTS; EPIGENETIC MEMORY; DIRECT CONVERSION; PROGENITOR CELLS; PATIENT; DIFFERENTIATION; NEURONS;

D O I：

10.1016/j.biopha.2019.108663

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The utilization of embryonic stem cells has ethical problems regarding the use of embryos in cell therapy and regenerative medicine, especially in neurodegenerative diseases. To overcome these ethical issues, induced Pluripotent Stem Cells and then transdifferentiation have presented to the science world which can be a good shortcut and solution to the ethical issues of traditional methods. Neurodegenerative diseases are difficult puzzles to combine and with modeling of these diseases by somatic cells reprogramming such as induced pluripotent stem cells induction or direct differentiation techniques, this could be solved. In the present study, we briefly review the techniques which used for neurodegenerative diseases' researches.

引用

页数：6

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