Systematic review and meta-analysis of randomized, controlled trials on the effects of soy and soy products supplementation on serum adiponectin levels

Background and aims: Our aim in this meta-analysis was to determine the effect of soy and soy product supplementation on serum adiponectin levels. Method: A systematic search was conducted using Medline (PubMed and Web of Science), Scopus, and Cochrane Library for eligible trials up to August 2020. A random-effects model was used to pool calculated effect sizes. Results: Seven trials were included in the overall analysis. Our analysis showed that soy and soy product supplementation did not significantly affect adiponectin concentrations (WMD =-0.77 mg/ml, 95% CI:-0.61, 2.15, P = 0.27) in comparison with a placebo. The between-study heterogeneity was high (I-2: 68.2%, P = 0.004). Subgroup analysis, based on participants' health status and duration of the supple-mentation, could not detect the potential source of the observed heterogeneity. In addition, subgroup analysis showed that the effect was not statistically significant in all subgroups. Conclusion: Overall, soy and soy product supplementation did not change the circulatory adiponectin levels. In addition, the results were not affected by the participant's health status and duration of sup-plementation. However, further studies are needed to confirm the present results. (c) 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.