Dietary Exposure and Risk Assessment of Aflatoxin M1 for Children Aged 1 to 9 Years Old in Serbia

被引:18
作者
Milicevic, Dragan R. [1 ]
Milesevic, Jelena [2 ]
Gurinovic, Mirjana [2 ]
Jankovic, Sasa [1 ]
Dinovic-Stojanovic, Jasna [1 ]
Zekovic, Milica [2 ]
Glibetic, Maria [2 ]
机构
[1] Inst Meat Hyg & Technol, Kacanskog 13, Belgrade 11040, Serbia
[2] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Ctr Res Excellence Nutr & Metab, Bulevar Oslobodenja 18, Belgrade 11000, Serbia
关键词
aflatoxin M1; milk; dairy products; risk assessment; children; MILK-PRODUCTS; FOOD; MYCOTOXINS; M-1; IMPACT; FEED;
D O I
10.3390/nu13124450
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The present study was conducted to estimate the exposure and characterize the risk for the child population of Serbia to Aflatoxin M1 (AFM1) from milk and milk-based food. A total of 3404 samples comprising milk and different milk-based food samples were collected from various regions of Serbia from 2017 to 2019. Evaluation of AFM1 exposure was carried out using the deterministic method, whereas risk characterization was evaluated using the margin of exposure (MOE) and the risk of hepatocellular carcinoma (HCC). Detection rates for AFM1 in milk and milk-based food samples ranged between 2% and 79%, with the highest incidence (79%) and mean level (22.34 +/- 0.018 ng kg(-1)) of AFM1 being detected in pasteurized and UHT milk. According to the three consumption estimates, the values of estimated daily intake (EDI) were higher for toddlers as compared with children aged 3-9 years. Children aged 1-3 years had the highest risk of exposure to AFM1 in milk, with an estimated daily intake of 0.164 and 0.193 ng kg(-1) bw day(-1) using lower bound (LB) and upper bound (UB) exposure scenarios, respectively. Such difference could result from the higher consumption to weight in younger children. Based on the estimated daily intake (EDI) found in this study, the risk of AFM1 exposure due to consumption of milk and milk-based food was low since the MOE values obtained were >10,000. In addition, the risk of HCC cases/year/10(5) individuals of different age groups showed that the value of HCC, using potency estimates of 0.0017 (mean), was maximum (0.00034) in the age group 1-3 years, which indicates no health risk for the evaluated groups. The present study revealed the importance of controlling and preventing AFM1 contamination in milk through continuous monitoring and regular inspection to reduce the risk of AFM1 exposure, especially in children.
引用
收藏
页数:14
相关论文
共 48 条
  • [41] Two year survey on the occurrence and seasonal variation of aflatoxin M1 in milk and milk products in Serbia
    Tomasevic, Igor
    Petrovic, Jelena
    Jovetic, Milica
    Raicevic, Smiljana
    Milojevic, Milica
    Miocinovic, Jelena
    [J]. FOOD CONTROL, 2015, 56 : 64 - 70
  • [42] Risk estimates of hepatocellular carcinoma in Vojvodina (Serbia) related to aflatoxin M1 contaminated cheese
    Torovic, Ljilja
    Popov, Nenad
    Zivkov-Balos, Milica
    Jaksic, Sandra
    [J]. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 2021, 103
  • [43] Aflatoxin M1 in milk: A global occurrence, intake, & exposure assessment
    Turna, Nikita Saha
    Wu, Felicia
    [J]. TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2021, 110 : 183 - 192
  • [44] Overview on the Mycotoxins Incidence in Serbia in the Period 2004-2016
    Udovicki, Bozidar
    Audenaert, Kris
    De Saeger, Sarah
    Rajkovic, Andreja
    [J]. TOXINS, 2018, 10 (07)
  • [45] Aflatoxin: food chain transfer from feed to milk
    Walte, Hans-Georg
    Schwake-Anduschus, Christine
    Geisen, Rolf
    Fritsche, Jan
    [J]. Journal fur Verbraucherschutz und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety, 2016, 11 (04): : 295 - 297
  • [46] Wild CP, 2015, IARC working group report, V9
  • [47] International incidence and mortality trends of liver cancer: a global profile
    Wong, Martin C. S.
    Jiang, Johnny Y.
    Goggins, William B.
    Liang, Miaoyin
    Fang, Yuan
    Fung, Franklin D. H.
    Leung, Colette
    Wang, Harry H. X.
    Wong, Grace L. H.
    Wong, Vincent W. S.
    Chan, Henry L. Y.
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [48] Zekovic M., 2021, EFSA SUPPORT PUBL, V18, p6994E