Fibroblast Growth Factors in Depression

被引：32

作者：

Deng, Zheng ^{[1
]}

Deng, Sheng ^{[2
,3
]}

Zhang, Mu-Rong ^{[2
,3
,4
]}

Tang, Mi-Mi ^{[2
,3
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Hosp Evaluat Off, Changsha, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China

[3] Cent S Univ, Inst Hosp Pharm, Changsha, Hunan, Peoples R China

[4] Cent S Univ, Xiangya Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷

基金：

中国国家自然科学基金;

关键词：

major depressive disorder; depression; fibroblast growth factor; fibroblast growth factor receptor; hippocampus; MESSENGER-RNA EXPRESSION; MAJOR DEPRESSION; FACTOR SYSTEM; HETERORECEPTOR COMPLEXES; HOMOLOGOUS FACTORS; PREFRONTAL CORTEX; FACTOR RECEPTOR-1; FGF; NEURONS; EVOLUTION;

D O I：

10.3389/fphar.2019.00060

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Major depressive disorder (MDD) is one of the most serious diseases and now becomes a major public health problem in the world. The pathogenesis of depression remains poorly understood. Fibroblast growth factors (FGFs) belong to a large family of growth factors that are involved in brain development during early periods as well as maintenance and repair throughout adulthood. In recent years, studies have found a correlation between the members of the FGF system and depression. These signaling molecules may be expected to be biomarkers for the diagnosis and prognosis of MDD, and may provide new drug targets for the treatment of depression. Here, we reviewed the correlation between some members of the FGF system and depression.

引用

页数：9

共 93 条

[1]

Alzheimer C, 2002, ADV EXP MED BIOL, V513, P335

[2] Fibroblast growth factor 9 is a novel modulator of negative affect [J].

Aurbach, Elyse L. ;

Inui, Edny Gula ;

Turner, Cortney A. ;

Hagenauer, Megan H. ;

Prater, Katherine E. ;

Li, Jun Z. ;

Absher, Devin ;

Shah, Najmul ;

Blandino, Peter, Jr. ;

Bunney, William E. ;

Myers, Richard M. ;

Barchas, Jack D. ;

Schatzberg, Alan F. ;

Watson, Stanley J. ;

Akil, Huda .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (38) :11953-11958

[3] Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons [J].

Bachis, Alessia ;

Mallei, Alessandra ;

Cruz, Maria Idalia ;

Wellstein, Anton ;

Mocchetti, Italo .

NEUROPHARMACOLOGY, 2008, 55 (07) :1114-1120

[4] Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfra, Olig2 and Plp/dm20:: Implications for oligodendrocyte development [J].

Bansal, R ;

Lakhina, V ;

Remedios, R ;

Tole, S .

DEVELOPMENTAL NEUROSCIENCE, 2003, 25 (2-4) :83-95

[5] The FGF family: biology, pathophysiology and therapy [J].

Beenken, Andrew ;

Mohammadi, Moosa .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (03) :235-253

[6] Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression [J].

Bernard, R. ;

Kerman, I. A. ;

Thompson, R. C. ;

Jones, E. G. ;

Bunney, W. E. ;

Barchas, J. D. ;

Schatzberg, A. F. ;

Myers, R. M. ;

Akil, H. ;

Watson, S. J. .

MOLECULAR PSYCHIATRY, 2011, 16 (06) :634-646

[7] Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress [J].

Berton, O ;

McClung, CA ;

DiLeone, RJ ;

Krishnan, V ;

Renthal, W ;

Russo, SJ ;

Graham, D ;

Tsankova, NM ;

Bolanos, CA ;

Rios, M ;

Monteggia, LM ;

Self, DW ;

Nestler, EJ .

SCIENCE, 2006, 311 (5762) :864-868

[8] FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression [J].

Borroto-Escuela, Dasiel O. ;

Tarakanov, Alexander O. ;

Fuxe, Kjell .

TRENDS IN NEUROSCIENCES, 2016, 39 (01) :5-15

[9] Fibroblast Growth Factor Receptor 1-5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity [J].

Borroto-Escuela, Dasiel O. ;

Romero-Fernandez, Wilber ;

Mudo, Giuseppa ;

Perez-Alea, Mileidys ;

Ciruela, Francisco ;

Tarakanov, Alexander O. ;

Narvaez, Manuel ;

Di Liberto, Valentina ;

Agnati, Luigi F. ;

Belluardo, Natale ;

Fuxe, Kjell .

BIOLOGICAL PSYCHIATRY, 2012, 71 (01) :84-91

[10] Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system [J].

Brooks, Leah R. ;

Enix, Courtney L. ;

Rich, Samuel C. ;

Magno, Jinno A. ;

Lowry, Christopher A. ;

Tsai, Pei-San .

BEHAVIOURAL BRAIN RESEARCH, 2014, 264 :74-81

← 1 2 3 4 5 6 7 8 9 10 →