Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell lines

被引：7
作者：
Ravichandran, Siranjeevi [1 ,2 ]
Radhakrishnan, Jeyalakshmi [1 ]
Nandhiraman, Vanaitha [1 ]
Mariappan, Mariappan [1 ]
机构：
[1] SRM Inst Sci & Technol SRMIST, Dept Chem, Kattankulathur 603203, Tamil Nadu, India
[2] Saveetha Univ, Saveetha Sch Engn, Saveetha Inst Med & Tech Sci, Dept Chem, Chennai 602105, Tamil Nadu, India
来源：
RESULTS IN CHEMISTRY | 2022年 / 4卷
关键词：
Ruthenium complexes; Electrospinning; Polycaprolactone; Anticancer activity; ELECTROSPUN NANOFIBERS; DRUG-RELEASE; COMPOSITE; SCAFFOLD; BIOMATERIAL; GRAPHENE; DELIVERY; EXTRACT;
D O I：
10.1016/j.rechem.2022.100380
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The objective of this work was to advance implantable Ruthenium complexes incorporated polycaprolactone (PCL-Ru) electrospun nanofibers, which might hold great potential for cancer diagnosis. Ruthenium complex was infused into biodegradable PCL nanofibers by the electrospinning method and was characterized for their structural and surface morphology using FESEM, HRTEM, and XRD. The chemical analysis was performed through FTIR and UV-Vis. The mechanical strength and thermal behavior of the electrospun nanofibrous have been examined in this study. The average diameter of pristine PCL and PCL-Ru nanofibers was 617.91 +/- 165 nm and 426.77 +/- 14 nm. The in vitro anticancer activity of Ru-complexes infused PCL nanofibers was assessed against liver (Hep-G2), oral cancer (HSC-3), renal cell carcinomas (ACHN), and lung (L-132) cancer cell lines, as well as the release profile of the Ru-complexes, infused PCL nanofibers. According to the results, Ru-complexes containing PCL may be easily infused into nanofibers and have a very uniform distribution inside them. More significantly, the Ru-complexes produced by the blended nanofibers can be released for an extended of period time, resulting in significant anticancer efficacy in vitro.
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页数：9
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共 42 条
[21]   Simultaneous controlled release of 5-FU, DOX and PTX from chitosan/PLA/5-FU/g-C3N4-DOX/g-C3N4-PTX triaxial nanofibers for breast cancer treatment in vitro [J].
Jouybari, Mania Habibi ;
Hosseini, Seyedehgolshan ;
Mahboobnia, Khadijeh ;
Boloursaz, Lily Azadeh ;
Moradi, Mostafa ;
Irani, Mohammad .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 179 :495-504
[22]   Preparation, characterization and antimicrobial activity evaluation of electrospun PCL nanofiber composites of resveratrol nanocrystals [J].
Karakucuk, Alptug ;
Tort, Serdar .
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2020, 25 (10) :1216-1225
[23]   A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle [J].
Kim, Kyoung Sub ;
Park, Wooram ;
Hu, Jun ;
Bae, You Han ;
Na, Kun .
BIOMATERIALS, 2014, 35 (01) :337-343
[24]   Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells [J].
Kim, Young-Jin ;
Park, Mi Ran ;
Kim, Min Sung ;
Kwon, Oh Hyeong .
MATERIALS CHEMISTRY AND PHYSICS, 2012, 133 (2-3) :674-680
[25]   Polycaprolactone nanofibres loaded with 20(S)-protopanaxadiol for in vitro and in vivo anti-tumour activity study [J].
Liu, Dan-qing ;
Cheng, Zhi-qiang ;
Feng, Qing-jie ;
Li, He-jie ;
Ye, Shu-feng ;
Teng, Bo .
ROYAL SOCIETY OPEN SCIENCE, 2018, 5 (05)
[26]   PCL/PVA nanoencapsulated reinforcing fillers of steam exploded/autoclaved cellulose nanofibrils for tissue engineering applications [J].
Manhas, Navdeep ;
Balasubramanian, K. ;
Prajith, P. ;
Rule, Prashant ;
Nimje, Sunil .
RSC ADVANCES, 2015, 5 (31) :23999-24008
[27]   Photoactivatable RuII Complex Bearing 2,9-Diphenyl-1,10-phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin-Resistant Cell Lines [J].
Mansour, Najwa ;
Mehanna, Stephanie ;
Mroueh, Mohamad A. ;
Audi, Hassib ;
Bodman-Smith, Kikki ;
Daher, Costantine F. ;
Taleb, Robin I. ;
El-Sibai, Mirvat ;
Khnayzer, Rony S. .
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2018, (22) :2524-2532
[28]   Electrospun herbal nanofibrous wound dressings for skin tissue engineering [J].
Mary, S. Agnes ;
Dev, V. R. Giri .
JOURNAL OF THE TEXTILE INSTITUTE, 2015, 106 (08) :886-895
[29]   Surface potential and roughness controlled cell adhesion and collagen formation in electrospun PCL fibers for bone regeneration [J].
Metwally, Sara ;
Ferraris, Sara ;
Spriano, Silvia ;
Krysiak, Zuzanna J. ;
Kaniuk, Lukasz ;
Marzec, Mateusz M. ;
Kim, Sung Kyun ;
Szewczyk, Piotr K. ;
Gruszczynski, Adam ;
Wytrwal-Sarna, Magdalena ;
Karbowniczek, Joanna E. ;
Bernasik, Andrzej ;
Kar-Narayan, Sohini ;
Stachewicz, Urszula .
MATERIALS & DESIGN, 2020, 194 (194)
[30]   Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition [J].
Mishra, Pratik ;
Ray, Sambit ;
Sinha, Sayantan ;
Das, Bhaskar ;
Khan, Md. Imran ;
Behera, Susant K. ;
Yun, Soon-Il ;
Tripathy, Suraj K. ;
Mishra, Amrita .
BIOCHEMICAL ENGINEERING JOURNAL, 2016, 105 :264-272
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