Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate

被引：28

作者：

Jasinska, Anna J. ^{[1
,2
]}

Zelaya, Ivette ^{[3
]}

Service, Susan K. ^{[1
]}

Peterson, Christine B. ^{[4
]}

Cantor, Rita M. ^{[1
,5
]}

Choi, Oi-Wa ^{[1
]}

DeYoung, Joseph ^{[1
]}

Eskin, Eleazar ^{[5
,6
]}

Fairbanks, Lynn A. ^{[1
]}

Fears, Scott ^{[1
]}

Furterer, Allison E. ^{[7
]}

Huang, Yu S. ^{[1
,23
]}

Ramensky, Vasily ^{[1
,24
]}

Schmitt, Christopher A. ^{[1
,25
]}

Svardal, Hannes ^{[8
]}

Jorgensen, Matthew J. ^{[9
]}

Kaplan, Jay R. ^{[9
]}

Villar, Diego ^{[10
]}

Aken, Bronwen L. ^{[11
]}

Flicek, Paul ^{[11
]}

Nag, Rishi ^{[11
]}

Wong, Emily S. ^{[11
]}

Blangero, John ^{[12
]}

Dyer, Thomas D. ^{[12
]}

Bogomolov, Marina ^{[13
]}

Benjamini, Yoav ^{[14
]}

Weinstock, George M. ^{[15
]}

Dewar, Ken ^{[16
]}

Sabatti, Chiara ^{[17
,18
]}

Wilson, Richard K. ^{[19
,26
]}

Jentsch, J. David ^{[20
,21
,27
]}

Warren, Wesley ^{[19
]}

Coppola, Giovanni ^{[1
,22
]}

Woods, Roger P. ^{[21
,22
]}

Freimer, Nelson B. ^{[1
,5
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet,Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[2] Polish Acad Sci, Inst Bioorgan Chem, Poznan, Poland

[3] Univ Calif Los Angeles, Interdept Program Bioinformat, Los Angeles, CA USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA

[5] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA

[6] Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90024 USA

[7] Univ Calif Los Angeles, Interdept Grad Program Neurosci, Los Angeles, CA USA

[8] Wellcome Trust Sanger Inst, Hinxton, England

[9] Wake Forest Sch Med, Dept Pathol, Winston Salem, NC USA

[10] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England

[11] European Bioinformat Inst, European Mol Biol Lab, Wellcome Trust Genome Campus, Hinxton, England

[12] UTRGV, UTHSCSA, South Texas Diabet & Obes Inst, Brownsville, TX USA

[13] Technion, Fac Ind Engn & Management, Haifa, Israel

[14] Tel Aviv Univ, Dept Stat & Operat Res, Tel Aviv, Israel

[15] Jackson Lab Genom Med, Farmington, CT USA

[16] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[17] Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA

[18] Stanford Univ, Dept Stat, Stanford, CA 94305 USA

[19] Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA

[20] Univ Calif Los Angeles, Dept Psychol, 405 Hilgard Ave, Los Angeles, CA 90024 USA

[21] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[22] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[23] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China

[24] Moscow Inst Phys & Technol, Dolgoprudnyi, Russia

[25] Boston Univ, Dept Anthropol, Boston, MA 02215 USA

[26] Nationwide Childrens Hosp, Inst Genom Med, Columbus, OH USA

[27] Binghamton Univ, Dept Psychol, Binghamton, NY USA

来源：

NATURE GENETICS | 2017年 / 49卷 / 12期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

CHLOROCEBUS-AETHIOPS-SABAEUS; GENOME-WIDE ASSOCIATION; MARIE-TOOTH DISEASE; VERVET MONKEY; HUMAN BRAIN; LINKAGE ANALYSIS; TRAITS; EVOLUTION; TRANSCRIPTOME; RNA;

D O I：

10.1038/ng.3959

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex-and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.

引用

页码：1714 / +

页数：13