Low-level rifampicin-resistant Mycobacterium tuberculosis strains raise a new therapeutic challenge

被引：56
|
作者：
van Ingen, J. [1 ,2 ]
Aarnoutse, R. [3 ]
de Vries, G. [4 ,5 ]
Boeree, M. J. [1 ]
van Soolingen, D. [1 ,2 ,6 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Pulm Dis, NL-6500 HB Nijmegen, Netherlands
[2] Natl Inst Publ Hlth & Environm, Natl TB Reference Lab, NL-3720 BA Bilthoven, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Clin Pharm, NL-6500 HB Nijmegen, Netherlands
[4] Municipal Publ Hlth Serv, Dept TB Control, Rotterdam, Netherlands
[5] KNCV TB Fdn, The Hague, Netherlands
[6] Radboud Univ Nijmegen, Med Ctr, Dept Clin Microbiol, NL-6500 HB Nijmegen, Netherlands
来源：
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2011年 / 15卷 / 07期
关键词：
tuberculosis; multidrug-resistant; rpoB protein; Mycobacterium tuberculosis; rifampicin; DOSE RIFAMPIN;
D O I：
10.5588/ijtld.10.0127
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In an outbreak of multidrug-resistant tuberculosis, the outbreak strain had an Asp516Tyr rpoB gene mutation. Phenotypically, low-level rifampicin (RMP) resistance (minimum inhibitory concentration [MIC] 1-2 mg/l) was observed. Based on drug susceptibility test results, three patients were treated with 12-15 month rifabutin-based regimens and one with a 12-month RMP-based regimen. We retrospectively performed pharmacokinetic calculations to assess the potential for RMP treatment, from which we conclude that MICs for RMP up to 1 mu g/ml may be safely overcome by applying 20 mg/kg RMP doses in treatment regimens.
引用
收藏
页码：990 / 992
页数：3
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