Molecular Signatures of Pancreatic Cancer

被引：16

作者：

Hong, Seung-Mo ^{[1
]}

Park, Jason Y. ^{[4
]}

Hruban, Ralph H. ^{[1
,3
]}

Goggins, Michael ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Med Inst, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21231 USA

[2] Johns Hopkins Med Inst, Dept Med, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21231 USA

[3] Johns Hopkins Med Inst, Dept Oncol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21231 USA

[4] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

来源：

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | 2011年 / 135卷 / 06期

关键词：

PAPILLARY-MUCINOUS NEOPLASMS; PEUTZ-JEGHERS GENE; GIANT-CELL TUMORS; K-RAS MUTATIONS; ABERRANT METHYLATION; MICRORNA EXPRESSION; MULTIPLE GENES; UNDIFFERENTIATED CARCINOMA; INTRAEPITHELIAL NEOPLASIA; DUCTAL ADENOCARCINOMA;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Context.-The introduction of genome-and epigenome-wide screening techniques has dramatically improved our understanding of the molecular mechanisms underlying the development of pancreatic cancer. There are now 3 recognized histologic precursors of pancreatic cancer: pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. Each of these precursor lesions is associated with specific molecular alterations. Objective.-To understand the molecular characteristics of pancreatic ductal adenocarcinoma and its precursor lesions. Data Sources.-PubMed (US National Library of Medicine). Conclusions.-In this review, we briefly summarize recent research findings on the genetics and epigenetics of pancreatic cancer. In addition, we characterize these molecular alterations in the context of the histologic subtypes of pancreatic cancer. (Arch Pathol Lab Med. 2011;135:716-727)

引用

页码：716 / 727

页数：12

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