Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation

被引：105

作者：

Van Oss, S. Branden ^{[1
]}

Cucinotta, Christine E. ^{[1
]}

Arndt, Karen M. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2017年 / 42卷 / 10期

关键词：

RNA-POLYMERASE-II; TRANSCRIPTION ELONGATION-FACTORS; HISTONE H2B UBIQUITYLATION; SACCHAROMYCES-CEREVISIAE; TUMOR-SUPPRESSOR; CRYPTIC TRANSCRIPTION; PROCESSING FACTORS; UBIQUITIN LIGASE; RTF1; PROTEIN; IN-VIVO;

D O I：

10.1016/j.tibs.2017.08.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a diverse set of recent studies from various organisms that build on foundational studies in budding yeast. These studies identify new roles for Paf1C in the control of gene expression and the regulation of chromatin structure. In exploring these advances, we find that various functions of Paf1C, such as the regulation of promoter-proximal pausing and development in higher eukaryotes, are complex and context dependent. As more becomes known about the role of Paf1C in human disease, interest in the molecular mechanisms underpinning Paf1C function will continue to increase.

引用

页码：788 / 798

页数：11

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