Meta-analysis of whole-genome linkage scans for intracranial aneurysm

被引：13

作者：

Biros, Erik ^{[1
]}

Golledge, Jonathan ^{[1
]}

机构：

[1] James Cook Univ N Queensland, Sch Med, Dept Surg, Vasc Biol Unit, Townsville, Qld 4811, Australia

来源：

NEUROSCIENCE LETTERS | 2008年 / 431卷 / 01期

关键词：

intracranial aneurysm; genome linkage scan; meta-analyses;

D O I：

10.1016/j.neulet.2007.11.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genetic predisposition likely plays an important role in the development of intracranial aneurysms. We carried out a genome search meta-analysis to identified loci associated with intracranial aneurysm. We identified previous whole-genome linkage analyses by searching PUBMED. Five studies reported by separate investigators where detailed data could be obtained were included in our analysis. We synthesized the available genome-wide scan data by using a heterogeneity-based genome search meta-analyses. We identified two linkage sites on chromosomes 3 and 17 which had P-values <0.01 for association with intracranial aneurysm. Our findings confirm the association of a locus on chromosome 17 and identify a new linkage site on chromosome 3 for intracranial aneurysm. The new locus contains a number of potential gene candidates including kininogen-1 precursor, fibroblast growth factor-12 and endothelin converting enzyme 2. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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页码：31 / 35

页数：5

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