Integration of mechanism-based in vitro methods and quantitative in vitro-in vivo extrapolation (QIVIVE) modelling for prediction of nephrotoxicity

被引:0
|
作者
Mally, A. [1 ]
Birk, B. [2 ]
DiFiore, S. [3 ]
Ellinger, B. [4 ]
Jarzina, S. [1 ]
Taverne, F. [5 ]
Kramer, N. [5 ]
机构
[1] Univ Wurzburg, Dept Toxicol, Wurzburg, Germany
[2] BASF, Expt Toxicol & Ecol, Ludwigshafen, Germany
[3] Fraunhofer Inst Mol Biol & Appl Ecol, Div Mol Biotechnol, Aachen, Germany
[4] Fraunhofer Inst Mol Biol & Appl Ecol, Div Translat Med, Hamburg, Germany
[5] Univ Utrecht, Inst Risk Assessment Sci, Toxicol Div, Utrecht, Netherlands
关键词
D O I
10.1016/j.toxlet.2018.06.1123
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
S08-02
引用
收藏
页码:S27 / S27
页数:1
相关论文
共 50 条
  • [1] Application of adverse outcome pathways and quantitative in vitro-in vivo extrapolation (QIVIVE) modelling for risk assessment based on in vitro data
    Mally, A.
    Birk, B.
    Di Fiore, S.
    Ellinger, B.
    Jarzina, S.
    Reiser, P.
    Taverne, F.
    Kramer, N.
    TOXICOLOGY LETTERS, 2019, 314 : S140 - S140
  • [2] In vitro kinetics in quantitative in vitro-in vivo extrapolation
    Kramer, Nynke I.
    TOXICOLOGY LETTERS, 2016, 258 : S4 - S4
  • [3] A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation
    Smith, Andrew K.
    Xu, Yanli
    Ropella, Glen E. P.
    Hunt, C. Anthony
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2018, 365 (01): : 127 - 138
  • [4] In vitro kinetics and quantitative in vitro-in vivo extrapolation of nephrotoxicants
    Kramer, N.
    Taverne, F.
    Mally, A.
    Jarzina, S.
    Birk, B.
    DiFiore, S.
    Ellinger, B.
    Gehring, R.
    TOXICOLOGY LETTERS, 2018, 295 : S137 - S137
  • [5] Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment
    Yoon, Miyoung
    Blaauboer, Bas J.
    Clewell, Harvey J.
    TOXICOLOGY, 2015, 332 : 1 - 3
  • [6] Quantitative Prediction of Glucuronidation in Humans Using the In Vitro-In Vivo Extrapolation Approach
    Wu, Baojian
    Dong, Dong
    Hu, Ming
    Zhang, Shuxing
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2013, 13 (11) : 1343 - 1352
  • [7] Principles of quantitative In Vitro to in vivo extrapolation (QIVIVE) applying physiologically based kinetic (PBK) modelling for DNT IVB
    Paini, A.
    Louisse, J.
    Sachana, M.
    Tan, C.
    TOXICOLOGY LETTERS, 2024, 399 : S37 - S38
  • [8] Development of physiologically based pharmacokinetic (PBPK) models for quantitative in vitro-in vivo extrapolations (QIVIVE)
    Punt, A.
    TOXICOLOGY LETTERS, 2022, 368 : S5 - S5
  • [9] Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data
    Wilk-Zasadna, Iwona
    Bernasconi, Camilla
    Pelkonen, Olavi
    Coecke, Sandra
    TOXICOLOGY, 2015, 332 : 8 - 19
  • [10] Physiologically based approaches towards the prediction of pharmacokinetics:: in vitro-in vivo extrapolation
    De Buck, Stefan S.
    Mackie, Claire E.
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2007, 3 (06) : 865 - 878