The Effects of Estrogen and Progesterone on Blood Glutamate Levels: Evidence from Changes of Blood Glutamate Levels During the Menstrual Cycle in Women

被引：46

作者：

Zlotnik, Alexander ^{[1
]}

Gruenbaum, Benjamin F. ^{[1
]}

Mohar, Boaz ^{[5
]}

Kuts, Ruslan ^{[1
]}

Gruenbaum, Shaun E. ^{[3
]}

Ohayon, Sharon ^{[1
]}

Boyko, Matthew ^{[1
]}

Klin, Yael ^{[5
]}

Sheiner, Eyal ^{[2
]}

Shaked, Gad ^{[4
]}

Shapira, Yoram ^{[1
]}

Teichberg, Vivian I. ^{[5
]}

机构：

[1] Ben Gurion Univ Negev, Soroka Med Ctr, Dept Anesthesiol & Crit Care, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Soroka Med Ctr, Dept Obstet & Gynecol, IL-84105 Beer Sheva, Israel

[3] Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06510 USA

[4] Ben Gurion Univ Negev, Soroka Med Ctr, Dept Gen Surg, IL-84105 Beer Sheva, Israel

[5] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

来源：

BIOLOGY OF REPRODUCTION | 2011年 / 84卷 / 03期

关键词：

estradiol; glutamate; menstrual cycle; neuroendocrinology; progesterone; CEREBROSPINAL-FLUID; SCAVENGING ACTIVITY; ALZHEIMERS-DISEASE; EXCESS GLUTAMATE; BRAIN INJURY; AMINO-ACIDS; ESTRADIOL; RECEPTOR; MECHANISMS; RELEASE;

D O I：

10.1095/biolreprod.110.088120

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gonadal steroids estrogen and progesterone have been shown to have neuroprotective properties against various neurodegenerative conditions. Excessive concentrations of glutamate have been found to exert neurotoxic properties. We hypothesize that estrogen and progesterone provide neuroprotection by the autoregulation of blood and brain glutamate levels. Venous blood samples (10 ml) were taken from 31 men and 45 women to determine blood glutamate, estrogen, progesterone, glucose, glutamate-pyruvate transaminase (GPT), and glutamate-oxaloacetate transaminase (GOT) levels, collected on Days 1, 7, 12, and 21 of the female participants' menstrual cycle. Blood glutamate concentrations were higher in men than in women at the start of menstruation (P < 0.05). Blood glutamate levels in women decreased significantly on Days 7 (P < 0.01), 12 (P < 0.001), and 21 (P < 0.001) in comparison with blood glutamate levels on Day 1. There was a significant decrease in blood glutamate levels on Days 12 (P < 0.001) and 21 (P < 0.001) in comparison with blood glutamate levels on Day 7. Furthermore, there was an increase in blood glutamate levels on Day 21 compared with Day 12 (P < 0.05). In women, there were elevated levels of estrogen on Days 7 (P < 0.05), 12, and 21 (P < 0.001), and elevated levels of progesterone on Days 12 and 21 (P < 0.001). There were no differences between men and women with respect to blood glucose concentrations. Concentrations of GOT (P < 0.05) and GPT (P < 0.001) were significantly higher in men than in women during the entire cycle. The results of this study demonstrate that blood glutamate levels are inversely correlated to levels of plasma estrogen and progesterone.

引用

页码：581 / 586

页数：6

共 60 条

[1] SIMULTANEOUS RADIOIMMUNOASSAY OF PLASMA FSH, LH, PROGESTERONE, 17-HYDROXYPROGESTERONE, AND ESTRADIOL-17BETA DURING MENSTRUAL-CYCLE [J].