The relation between MRI measures of inflammation and neurodegeneration in multiple sclerosis

被引：23
|
作者：
Inglese, M
Benedetti, B
Filippi, M
机构：
[1] Inst Sci, Dept Neurol, Neuroimaging Res Unit, I-20132 Milan, Italy
[2] Univ Osped San Raffaele, I-20132 Milan, Italy
[3] CUNY, Sch Med, Dept Radiol, New York, NY 10031 USA
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2005年 / 233卷 / 1-2期
关键词：
multiple sclerosis; magnetic resonance imaging; inflammation; neurodegeneration;
D O I：
10.1016/j.jns.2005.03.001
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Gadolinium-enhanced magnetic resonance imaging (MRI) and measures of brain volume have been extensively applied in large-scale studies to assess disease activity and irreversible tissue damage in multiple sclerosis (MS). Although histopathological studies of MS demonstrated that axonal transection occurs at sites of inflammatory changes, the correlation between brain tissue loss and gadolinium enhancement was found to be either absent or poor in virtually all in vivo MRI studies. This review discusses the reasons of this "inflammation/neurodegeneration mismatch" in MS and proposes possible strategies for a better in vivo characterization of the complex pathological process of this disease. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：15 / 19
页数：5
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