SHORT-TERM ENVIRONMENTAL ENRICHMENT ENHANCES SYNAPTIC PLASTICITY IN HIPPOCAMPAL SLICES FROM AGED RATS

被引:39
作者
Stein, Liana R. [1 ,5 ,6 ]
O'Dell, Kazuko A. [1 ,2 ]
Funatsu, Michiyo [1 ]
Zorumski, Charles F. [1 ,2 ,3 ,4 ]
Izumi, Yukitoshi [1 ,2 ,3 ]
机构
[1] Washington Univ, Sch Med, Dept Psychiat, 660 South Euclid Ave, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Taylor Family Inst Innovat Psychiat Res, 660 South Euclid Ave, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Ctr Brain Res Mood Disorders, 660 South Euclid Ave, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Neurosci, 660 South Euclid Ave, St Louis, MO 63110 USA
[5] Univ Calif San Francisco, Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA
[6] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA
关键词
environmental enrichment; long-term potentiation; long-term depression; N-methyl-D-aspartate receptor; aging; SPATIAL-LEARNING DEFICITS; NMDA RECEPTOR ACTIVATION; WEANING SOCIAL-ISOLATION; BEHAVIORAL STRESS; DENTATE GYRUS; CA1; REGION; INCREASED SUSCEPTIBILITY; COGNITIVE IMPAIRMENT; NEUROTROPHIC FACTOR; FISCHER-344; RATS;
D O I
10.1016/j.neuroscience.2016.05.020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Age-associated changes in cognition are mirrored by impairments in cellular models of memory and learning, such as long-term potentiation (LTP) and long-term depression (LTD). In young rodents, environmental enrichment (EE) can enhance memory, alter LTP and LTD, as well as reverse cognitive deficits induced by aging. Whether short-term EE can benefit cognition and synaptic plasticity in aged rodents is unclear. Here, we tested if short-term EE could overcome age-associated impairments in induction of LTP and LTD. LTP and LTD could not be induced in the CA1 region of hippocampal slices in control, aged rats using standard stimuli that are highly effective in young rats. However, exposure of aged littermates to EE for three weeks enabled successful induction of LTP and LTD. EE-facilitated LTP was dependent upon N-methyl-D-aspartate receptors (NMDARs). These alterations in synaptic plasticity occurred with elevated levels of phosphorylated cAMP response element-binding protein and vascular endothelial growth factor, but in the absence of changes in several other synaptic and cellular markers. Importantly, our study suggests that even a relatively short period of EE is sufficient to alter synaptic plasticity and molecular markers linked to cognitivefunction in aged animals. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:294 / 305
页数:12
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