Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems

被引：53
作者：
Hasumi, Keiji [1 ]
Yamamichi, Shingo [1 ]
Harada, Tomotaka [1 ]
机构：
[1] Tokyo Noko Univ, Dept Appl Biol Sci, Fuchu, Tokyo 1838509, Japan
来源：
FEBS JOURNAL | 2010年 / 277卷 / 18期
关键词：
coagulation; conformation; fibrinolysis; plasma hyaluronan-binding protein; plasminogen; plasminogen activator; protease; prothrombin; urokinase; zymogen activation; TISSUE PLASMINOGEN-ACTIVATOR; UROKINASE-CATALYZED ACTIVATION; HYALURONAN-BINDING PROTEIN; HEPATOCYTE GROWTH-FACTOR; HUMAN SARCOMA-CELLS; FACTOR-VII; SERINE-PROTEASE; GLU-PLASMINOGEN; LYS-PLASMINOGEN; FACTOR-VA;
D O I：
10.1111/j.1742-4658.2010.07783.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The coagulation and fibrinolytic systems are central to the hemostatic mechanism, which works promptly on vascular injury and tissue damage. The rapid response is generated by specific molecular interactions between components in these systems. Thus, the regulation mechanism of the systems is programmed in each component, as exemplified by the elegant processes in zymogen activation. This review describes recently identified small molecules that modulate the activation of zymogens in the fibrinolytic and coagulation systems.
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收藏
页码：3675 / 3687
页数：13
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