Myeloperoxidase activity and acute coronary syndrome survival: long-term evaluation in the ERICO study

被引：2

作者：

Quidim, Alessandra V. L. ^{[1
]}

Bruno, Tatiana C. ^{[1
]}

Lacerda Leocadio, Paola Caroline ^{[2
]}

dos Reis Menta, Penelope Lacrisio ^{[2
]}

Alvarez-Leite, Jacqueline Isaura ^{[2
]}

Santos, Itamar S. ^{[1
,3
]}

Lotufo, Paulo A. ^{[1
,3
]}

Bensenor, Isabela M. ^{[1
,3
]}

Goulart, Alessandra C. ^{[1
]}

机构：

[1] Univ Sao Paulo, Univ Hosp, Dept Internal Med, Ctr er Clin & Epidemiol Res, Sao Paulo, Brazil

[2] Univ Fed Minas Gerais, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil

[3] Univ Sao Paulo, Sch Med, Dept Internal Med, Sao Paulo, Brazil

来源：

BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 11期

关键词：

acute coronary syndrome; angina; inflammation; mortality; myeloperoxidase activity; myocardial infarction; oxidative stress; SERUM MYELOPEROXIDASE; HEART-DISEASE; MORTALITY; ATHEROSCLEROSIS; INFLAMMATION; MECHANISMS; BURDEN;

D O I：

10.2217/bmm-2018-0110

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We aimed to analyze the influence of myeloperoxidase (MPO) activity on mortality in the Acute Coronary Syndrome Registry Strategy (ERICO) study. Methods: MPO activity levels were evaluated in 342 patients. We performed survival analyses using Kaplan-Meier curves and Cox regression with respective hazard ratios, 95% CI, according to MPO tertiles distribution up to 7 years of follow-up. Results: Higher MPO activity levels were seen in men, smokers, diabetics and those who were taking aspirin. MPO activity levels were neither significant in relation to mortality nor to survival rates up to seven years. Conclusion: We found no relationship between elevated levels of MPO activity post-acute coronary syndrome and mortality up to 7-years of follow-up in the ERICO study.

引用

页码：1219 / 1229

页数：11

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