Self-Assembled Peptide Nanostructures for ECM Biomimicry

被引：25
作者：
Marin, Davide [1 ]
Marchesan, Silvia [1 ]
机构：
[1] Univ Trieste, Chem & Pharmaceut Sci Dept, I-34127 Trieste, Italy
来源：
NANOMATERIALS | 2022年 / 12卷 / 13期
关键词：
self-assembly; peptides; proteins; RGD; collagen; ECM; hydrogels; biomaterials; biomimicry; nanofibrils; AMINO-ACID-SEQUENCE; CELL ATTACHMENT; SUPRAMOLECULAR HYDROGELS; CROSS-LINKING; FIBRONECTIN; ADHESION; SCAFFOLDS; PROMOTE; DESIGN; AMPHIPHILE;
D O I：
10.3390/nano12132147
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Proteins are functional building blocks of living organisms that exert a wide variety of functions, but their synthesis and industrial production can be cumbersome and expensive. By contrast, short peptides are very convenient to prepare at a low cost on a large scale, and their self-assembly into nanostructures and gels is a popular avenue for protein biomimicry. In this Review, we will analyze the last 5-year progress on the incorporation of bioactive motifs into self-assembling peptides to mimic functional proteins of the extracellular matrix (ECM) and guide cell fate inside hydrogel scaffolds.
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页数：17
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