Degradation of Poly(D,L-lactic acid)-b-poly(ethylene glycol) Copolymer and Poly(L-lactic acid) by Electron Beam Irradiation

被引：5

作者：

Miao, Peikai ^{[1
,2
]}

Wu, Dimeng ^{[1
]}

Zeng, Ke ^{[1
]}

Zhao, Chun'e ^{[1
]}

Xu, Guoliang ^{[1
]}

Huang, Zhifu ^{[1
]}

Yang, Gang ^{[1
]}

机构：

[1] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Applicat & Res Ctr Elect Beams,Coll Polymer NHVC, Chengdu 610065, Peoples R China

[2] Hunan Sokan New Mat Co Ltd, Tech R&D Dept, R&D Ctr, Ningxiang 410600, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2011年 / 120卷 / 01期

关键词：

biopolymer; crosslinking; degradation; electron beam irradiation; molecular structure; MICROSPHERES;

D O I：

10.1002/app.33174

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This article investigated the effects of electron beam (EB) irradiation on poly(D, L-lactic acid)-b-poly(ethylene glycol) copolymer (PLEG) and poly(L-lactic acid) (PLLA). The dominant effect of EB irradiation on both PLEG and PLLA was chain scission. With increasing dose, recombination reactions or partial crosslinking of PLEG can occur in addition to chain scission, but there was no obvious crosslinking for PLLA at doses below 200 kGy. The chain scission degree of irradiated PLEG and PLLA was calculated to be 0.213 and 0.403, respectively. The linear relationships were also established between the decrease in molecular weight with increasing dose. Elongation at break of the irradiated PLEG and PLLA decreased significantly, whereas the tensile strength and glass transition temperature of PLLA decreased much more significantly compared with PLEG. The presence of poly(ethylene glycol) (PEG) chain segment in PLEG was the key factor in its greater stability to EB irradiation compared with PLLA. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 509-517, 2011

引用

页码：509 / 517

页数：9

共 33 条

[11]

Lewis D.H., 1990, Biodegradable polymers as drug delivery systems, P1

[12] Degradation of poly(lactide-co-glycolide) (PLGA) and poly(L-lactide) (PLLA) by electron beam radiation [J].

Loo, JSC ;

Ooi, CP ;

Boey, FYC .

BIOMATERIALS, 2005, 26 (12) :1359-1367

[13] Drug Release From Irradiated PLGA and PLLA Multi-Layered Films [J].

Loo, Say Chye Joachim ;

Tan, Zhi Ying Serlin ;

Chow, Yi Jun ;

Lin, Siew Ling Ivy .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 99 (07) :3060-3071

[14] Hydrolytic degradation of electron beam irradiated high molecular weight and non-irradiated moderate molecular weight PLLA [J].

Loo, SCJ ;

Tan, HT ;

Ooi, CP ;

Boey, YCF .

ACTA BIOMATERIALIA, 2006, 2 (03) :287-296

[15] Influence of electron-beam radiation on the hydrolytic degradation behaviour of poly(lactide-co-glycolide) (PLGA) [J].

Loo, SCJ ;

Ooi, CP ;

Boey, YCF .

BIOMATERIALS, 2005, 26 (18) :3809-3817

[16] Radiation effects on poly(lactide-co-glycolide) (PLGA) and poly(L-lactide) (PLLA) [J].

Loo, SCJ ;

Ooi, CP ;

Boey, YCF .

POLYMER DEGRADATION AND STABILITY, 2004, 83 (02) :259-265

[17] Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel [J].

Metters, AT ;

Anseth, KS ;

Bowman, CN .

POLYMER, 2000, 41 (11) :3993-4004

[18] Influence of electron beam pre-irradiation on the thermal behaviors of polyacrylonitrile [J].

Miao, Peikai ;

Wu, Dimeng ;

Zeng, Ke ;

Xu, Guoliang ;

Zhao, Chun'e ;

Yang, Gang .

POLYMER DEGRADATION AND STABILITY, 2010, 95 (09) :1665-1671

[19]

Miao PK, 2010, E-POLYMERS

[20] Degradation of Poly(D,L-lactic acid)-b-poly(ethylene glycol)-b-poly(D,L-lactic acid) Copolymer by Electron Beam Radiation [J].

Miao, Peikai ;

Zhao, Chun'e ;

Xu, Guoliang ;

Fu, Qiang ;

Tang, Wenrui ;

Zeng, Ke ;

Wang, Yipeng ;

Zhou, Hongfei ;

Yang, Gang .

JOURNAL OF APPLIED POLYMER SCIENCE, 2009, 112 (05) :2981-2987

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