DNA/BSA binding studies of peripherally tetra substituted neutral azophenoxy zinc phthalocyanine

被引：12

作者：

Amitha, G. S. ^{[1
]}

Vasudevan, Suni ^{[1
]}

机构：

[1] Natl Inst Technol Calicut, Dept Chem, Calicut 673601, Kerala, India

来源：

POLYHEDRON | 2020年 / 175卷

关键词：

ZnPc-4; CT-DNA; Fluorescent Intercalator Displacement (FID) assay; Binding constant; BSA; DNA-BINDING; PHOTOCHEMICAL PROPERTIES; IN-VIVO; PHOTOSENSITIZERS; CYTOTOXICITY; FLUORESCENCE; COMPLEXES; AGENTS; OXYGEN;

D O I：

10.1016/j.poly.2019.114208

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A tetra substituted neutral zinc phthalocyanine (ZnPc-4) bearing 4-phenylazophenoxy group at the periphery had been prepared from zinc acetate dihydrate Zn(CH3COO)(2)center dot 2H(2)O and 4-(phenylazophenoxy)phthalonitrile. The interaction of neutral metallophthalocyanine, ZnPc-4 with Calf Thymus (CT) DNA was investigated using absorption titrations, competitive Fluorescent Intercalator Displacement (FID) assay, minor groove binding assay and viscosity measurement. The binding studies revealed a probable intercalative mode of interaction of ZnPc-4 with DNA with an appreciable binding constant. The bovine serum albumin (BSA) binding activity of ZnPc-4 was evaluated by fluorescence titration. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页数：6

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