Hydrogels to model 3D in vitro microenvironment of tumor vascularization

被引：116
作者：
Song, Hyun-Ho Greco
Park, Kyung Min
Gerecht, Sharon [1 ]
机构：
[1] Johns Hopkins Phys Sci Oncol Ctr, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2014年 / 79-80卷
关键词：
Angiogenesis; Hydrogel; Tumor modeling; Three-dimensional cell culture; ECM remodeling; EXTRACELLULAR-MATRIX; ANTIANGIOGENIC THERAPY; ENDOTHELIAL-CELLS; PROSTATE-CANCER; MICROVASCULAR NETWORKS; ENGINEERING TUMORS; ANTITUMOR-ACTIVITY; LYMPHATIC VESSELS; CULTURE MODELS; DRUG-DELIVERY;
D O I：
10.1016/j.addr.2014.06.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A growing number of failing clinical trials for cancer therapy are substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is still very new. In this review, we explore current use of hydrogels and their design parameters to engineer vasculogenesis and angiogenesis and to evaluate the angiogenic capability of cancerous cells and tissues. By coupling these hydrogels with other technologies such as lithography and three-dimensional printing, one can create an advanced microvessel model as microfluidic channels to more accurately capture the native angiogenesis process. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：19 / 29
页数：11
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