Precise control of RNA cleavage by ribozyme mimics

被引:37
作者
Daniher, AT [1 ]
Bashkin, JK [1 ]
机构
[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA
关键词
D O I
10.1039/a800818c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A highly-modified DNA building block, lacking both sugar and base moieties, is synthesized and incorporated into oligonucleotides to form functional mimics of ribozymes.
引用
收藏
页码:1077 / 1078
页数:2
相关论文
共 13 条
[1]   SEQUENCE-SPECIFIC CLEAVAGE OF HIV MESSENGER-RNA BY A RIBOZYME MIMIC [J].
BASHKIN, JK ;
FROLOVA, EI ;
SAMPATH, US .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (13) :5981-5982
[2]   Building blocks for ribozyme mimics: Conjugates of terpyridine and bipyridine with nucleosides [J].
Bashkin, JK ;
Xie, J ;
Daniher, AT ;
Sampath, U ;
Kao, JLF .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (07) :2314-2321
[3]   Oligonucleotides covalently linked to an acridine at artificial abasic site: Influence of linker length and the base-sequence [J].
Fukui, K ;
Iwane, K ;
Shimidzu, T ;
Tanaka, K .
TETRAHEDRON LETTERS, 1996, 37 (28) :4983-4986
[4]   Synthesis and properties of an oligonucleotide modified with an acridine derivative at the artificial abasic site [J].
Fukui, K ;
Morimoto, M ;
Segawa, H ;
Tanaka, K ;
Shimidzu, T .
BIOCONJUGATE CHEMISTRY, 1996, 7 (03) :349-355
[5]  
HUESKEN D, 1996, BIOCHEMISTRY-US, V35, P16591
[6]   The embedded ribonucleotide assay: A chimeric substrate for studying cleavage of RNA by transesterification [J].
Jenkins, LA ;
Bashkin, JK ;
Autry, ME .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (29) :6822-6825
[7]   TRIVALENT LANTHANIDE IONS DO NOT CLEAVE RNA IN DNA-RNA HYBRIDS [J].
KOLASA, KA ;
MORROW, JR ;
SHARMA, AP .
INORGANIC CHEMISTRY, 1993, 32 (19) :3983-3984
[8]   RAPID HYDROLYSIS OF RNA WITH A CU-II COMPLEX [J].
LINKLETTER, B ;
CHIN, J .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (04) :472-474
[9]   Catalysis of phosphodiester transesterification by Cu(II)-terpyridine complexes with peripheral pendent base groups: Implications for the mechanism [J].
Liu, SH ;
Hamilton, AD .
TETRAHEDRON LETTERS, 1997, 38 (07) :1107-1110
[10]   Metal complex conjugates of antisense DNA which display ribozyme-like activity [J].
Magda, D ;
Wright, M ;
Crofts, S ;
Lin, A ;
Sessler, JL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (29) :6947-6948