Lower serum 25 (OH) D concentrations in type 1 diabetes: A meta-analysis

被引：65

作者：

Feng, Rennan ^{[1
,2
]}

Li, Yanchuan ^{[1
,2
]}

Li, Guoqiang ^{[3
]}

Li, Zhen ^{[1
,2
]}

Zhang, Yingfeng ^{[1
,2
]}

Li, Qiang ^{[4
]}

Sun, Changhao ^{[1
,2
]}

机构：

[1] Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin 150081, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Natl Key Discipline, Harbin 150081, Heilongjiang, Peoples R China

[3] Harbin Med Univ, Dean Off, Harbin 150081, Heilongjiang, Peoples R China

[4] Harbin Med Univ, Affiliated Hosp 2, Dept Endocrinol, Harbin 150081, Heilongjiang, Peoples R China

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2015年 / 108卷 / 03期

关键词：

Type; 1; diabetes; Serum vitamin D; Meta-analysis; VITAMIN-D LEVELS; BONE-MINERAL DENSITY; GENE POLYMORPHISMS; HYPOVITAMINOSIS D; HIGH PREVALENCE; D DEFICIENCY; CHILDREN; MELLITUS; ADOLESCENTS; WOMEN;

D O I：

10.1016/j.diabres.2014.12.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Vitamin D may have protective effects against type 1 diabetes (T1D). However, the results of current cross-sectional studies have been inconsistent. We aimed to examine the association of serum vitamin D and T1D by conducting a meta-analysis. Methods: Multiple databases were searched until April 2014 to identify relevant studies. The search term was "serum vitamin D" and "type 1 diabetes". Random effects model was used to calculate the pooled risk estimate. The data were accessed by software Review manager 5.2. Results: We included a total of 23 studies (11 studies with 1900 participants of children or adolescents and 13 studies with 3494 participants of adults) in our meta-analysis. In children or adolescents, serum 25(OH) D in T1D was 5.69 ng/ml [95% confidence interval (CI) (2.82-8.55, P < 0.0001) lower than in healthy controls. In adults, serum 25(OH) D in T1D was 2.61 ng/ml [95% confidence interval (CI) (1.13-4.09, P = 0.0005) lower than in healthy controls. We did not find evidence of publication bias. Conclusion: Serum 25OHD is significantly lower in patients with T1D than in healthy controls. (c) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E71 / E75

页数：5

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