CCL2/CCR2 signaling in cancer pathogenesis

被引：249

作者：

Hao, Qiongyu ^{[1
,2
]}

Vadgama, Jaydutt V. ^{[1
,2
]}

Wang, Piwen ^{[1
,2
,3
]}

机构：

[1] Charles R Drew Univ Med & Sci, Div Canc Res & Training, Los Angeles, CA 90059 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Ctr Human Nutr, Los Angeles, CA 90095 USA

来源：

CELL COMMUNICATION AND SIGNALING | 2020年 / 18卷 / 01期

关键词：

MONOCYTE CHEMOATTRACTANT PROTEIN-1; TUMOR-ASSOCIATED MACROPHAGES; LYMPH-NODE METASTASIS; PROSTATE-CANCER; CHEMOTACTIC PROTEIN-1; SUPPRESSOR-CELLS; ADIPOSE-TISSUE; CC-CHEMOKINE; INSULIN-RESISTANCE; DENDRITIC CELLS;

D O I：

10.1186/s12964-020-00589-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer. The progression and metastasis of prostate cancer involve a complex network of chemokines that regulate the recruitment and trafficking of immune cells. The chemokine CCL2 and its main receptor CCR2 have been receiving particular interest on their roles in cancer pathogenesis. The up-regulation of CCL2/CCR2 and varied immune conditions in prostate cancer, are associated with cancer advancement, metastasis, and relapse. Here we reviewed recent findings, which link CCL2/CCR2 to the inflammation and cancer pathogenesis, and discussed the therapeutic potential of CCL2/CCR2 axis in cancer treatment based on results from our group and other investigators, with a major focus on prostate cancer.

引用

页数：13

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