Two aspects of ASIC function: Synaptic plasticity and neuronal injury

被引:56
作者
Huang, Yan [1 ,2 ]
Jiang, Nan [3 ,4 ]
Li, Jun [1 ]
Ji, Yong-Hua [4 ]
Xiong, Zhi-Gang [2 ]
Zha, Xiang-ming [3 ]
机构
[1] Anhui Med Univ, Sch Pharm, Hefei, Peoples R China
[2] Morehouse Sch Med, Inst Neurosci, Atlanta, GA 30310 USA
[3] Univ S Alabama, Coll Med, Dept Physiol & Cell Biol, Mobile, AL 36688 USA
[4] Shanghai Univ, Lab Neuropharmacol & Neurotoxicol, Shanghai, Peoples R China
关键词
Proton; Acidosis; ASIC; Neuronal injury; Synaptic plasticity; SENSING ION CHANNELS; TRAUMATIC BRAIN-INJURY; MOLECULAR-CLONING; NA+ CHANNEL; MULTIPLE-SCLEROSIS; ACTIVATED CURRENTS; EXOCYTOSED PROTONS; CEREBRAL-ISCHEMIA; EXTRACELLULAR PH; RECEPTOR;
D O I
10.1016/j.neuropharm.2014.12.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Extracellular brain pH fluctuates in both physiological and disease conditions. The main postsynaptic proton receptor is the acid-sensing ion channels (ASICs). During the past decade, much progress has been made on protons, ASICs, and neurological disease. This review summarizes the recent progress on synaptic role of protons and our current understanding of how ASICs contribute to various types of neuronal injury in the brain. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:42 / 48
页数:7
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